2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases.

Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved in pathogenesis and progression of various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V2C) MXene nanoenzyme (MXenzyme) that can mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase (GPx), thiol peroxidase (TPx) and haloperoxidase (HPO). Based on these enzyme-mimicking properties, the constructed 2D V2C MXenzyme not only possesses high biocompatibility but also exhibits robust in vitro cytoprotection against oxidative stress. Importantly, 2D V2C MXenzyme rebuilds the redox homeostasis without perturbing the endogenous antioxidant status and relieves ROS-induced damage with benign in vivo therapeutic effects, as demonstrated in both inflammation and neurodegeneration animal models. These findings open an avenue to enable the use of MXenzyme as a remedial nanoplatform to treat ROS-mediated inflammatory and neurodegenerative diseases. Materials with enzymatic-like activities are of interest for a wide range of applications. Here, the authors report on 2D vanadium carbide MXene nanozymes capable of mimicking multiple enzymes and demonstrate application to treat reactive oxygen species-mediated inflammatory and neurodegenerative diseases.

活性氧（ROS）在生物体内因正常代谢而产生和消耗。矛盾的是，ROS的过量产生和/或管理不当与多种人类疾病的发病机制和进展有关。在此，我们报道了一种二维（2D）碳化钒（V2C）MXene纳米酶（MXenzyme），它能够模拟多达六种天然存在的酶，包括超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、过氧化物酶（POD）、谷胱甘肽过氧化物酶（GPx）、巯基过氧化物酶（TPx）和卤代过氧化物酶（HPO）。基于这些模拟酶的特性，所构建的2D V2C MXenzyme不仅具有高生物相容性，而且在体外对氧化应激表现出强大的细胞保护作用。重要的是，2D V2C MXenzyme在不干扰内源性抗氧化状态的情况下重建氧化还原稳态，并减轻ROS诱导的损伤，在体内具有良好的治疗效果，这在炎症和神经退行性动物模型中均得到证实。这些发现为将MXenzyme用作治疗ROS介导的炎症和神经退行性疾病的修复性纳米平台开辟了一条途径。 具有类酶活性的材料在广泛的应用中备受关注。在此，作者报道了能够模拟多种酶的二维碳化钒MXene纳米酶，并展示了其在治疗活性氧介导的炎症和神经退行性疾病方面的应用。