Adverse Pregnancy Outcomes and Long-term Maternal Kidney Disease A Systematic Review and Meta-analysis

Importance Adverse pregnancy outcomes, such as hypertensive disorders of pregnancy, gestational diabetes, and preterm delivery, are associated with increased risk of maternal cardiovascular disease. Little is known about whether adverse pregnancy outcomes are associated with increased risk of maternal chronic kidney disease (CKD) and end-stage kidney disease (ESKD). Objective To review and synthesize the published literature on adverse pregnancy outcomes (hypertensive disorders of pregnancy, gestational diabetes, and preterm delivery) and subsequent maternal CKD and ESKD. Data Sources PubMed, Embase, and Web of Science were searched from inception to July 31, 2019, for cohort and case-control studies of adverse pregnancy outcomes and maternal CKD and ESKD. Study Selection Selected studies included the following: a population of pregnant women, exposure to an adverse pregnancy outcome of interest, and at least 1 primary outcome (CKD or ESKD) or secondary outcome (hospitalization or death due to kidney disease). Adverse pregnancy outcomes included exposure to hypertensive disorders of pregnancy (preeclampsia, gestational hypertension, or chronic hypertension), preterm delivery (

重要性 不良妊娠结局，如妊娠期高血压疾病、妊娠期糖尿病和早产，与孕产妇心血管疾病风险增加有关。关于不良妊娠结局是否与孕产妇慢性肾脏病（CKD）和终末期肾脏病（ESKD）风险增加相关，人们知之甚少。 目的 回顾和综合已发表的关于不良妊娠结局（妊娠期高血压疾病、妊娠期糖尿病和早产）以及随后的孕产妇慢性肾脏病和终末期肾脏病的文献。 数据来源 从建库至2019年7月31日在PubMed、Embase和Web of Science中检索关于不良妊娠结局以及孕产妇慢性肾脏病和终末期肾脏病的队列研究和病例对照研究。 研究选择 入选的研究包括以下内容：孕妇人群、暴露于感兴趣的不良妊娠结局，以及至少1个主要结局（慢性肾脏病或终末期肾脏病）或次要结局（因肾脏病住院或死亡）。不良妊娠结局包括暴露于妊娠期高血压疾病（子痫前期、妊娠期高血压或慢性高血压）、早产（