Extracellular Vesicle-microRNAs as Diagnostic Biomarkers in Preterm Neonates.

Neonates born prematurely (<37 weeks of gestation) are at a significantly increased risk of developing inflammatory conditions associated with high mortality rates, including necrotizing enterocolitis, bronchopulmonary dysplasia, and hypoxic-ischemic brain damage. Recently, research has focused on characterizing the content of extracellular vesicles (EVs), particularly microRNAs (miRNAs), for diagnostic use. Here, we describe the most recent work on EVs-miRNAs biomarkers discovery for conditions that commonly affect premature neonates.

早产（妊娠<37周）的新生儿发生与高死亡率相关的炎症性疾病的风险显著增加，这些疾病包括坏死性小肠结肠炎、支气管肺发育不良和缺氧缺血性脑损伤。最近，研究重点是对细胞外囊泡（EVs）的内容物，特别是微小RNA（miRNAs）进行表征，以用于诊断。在此，我们描述了关于细胞外囊泡 - 微小RNA生物标志物发现的最新研究工作，这些生物标志物用于常见的影响早产新生儿的疾病。