Design and Synthesis of Poly(butyl acrylate) Networks through RAFT Polymerization with Crosslinking for Controlled-Release Applications

An effective approach is presented for designing and tailoring diffusion-controlled systems for targeted release rate profiles. The diffusion-controlled system consists of PBA networks with precisely controlled crosslink densities via RAFT copolymerization of BA with ethylene glycol dimethacrylate, which gives a desired diffusivity. One-dimensional releases in the crosslinked PBA matrix (CPM) slabs are evaluated with a hydrophobic dye. Fick's second law is used to model the transient mass transfers in the CPMs with a mixed Newton-Tikhonov regularization method for determination of their diffusion coefficients. A two-layer CPM (CPM-2) with controlled crosslink densities is constructed. The dye release results from the CPM-2 agreed well with theoretical predictions.

提出了一种有效的方法，用于设计和定制具有目标释放速率曲线的扩散控制体系。该扩散控制体系由通过丙烯酸丁酯（BA）与乙二醇二甲基丙烯酸酯的可逆加成 - 断裂链转移（RAFT）共聚精确控制交联密度的聚丙烯酸丁酯（PBA）网络组成，从而获得所需的扩散率。利用疏水性染料评估交联的PBA基质（CPM）板中的一维释放。采用菲克第二定律对CPM中的瞬态传质进行建模，并使用混合的牛顿 - 吉洪诺夫正则化方法确定其扩散系数。构建了一种具有可控交联密度的双层CPM（CPM - 2）。CPM - 2的染料释放结果与理论预测吻合良好。