Microwave-Assisted Polyol Synthesis of Gadolinium-Doped Green Luminescent Carbon Dots as a Bimodal Nanoprobe

The development of multimodal nanoprobes is highly desired in medical imaging because it integrates the advantages of multiple imaging modes. In this study, the gadolinium-doped green luminescent carbon dots (Gd-CDs) were prepared by the simple one-step microwave-assisted polyol method. The obtained Gd-CDs emitted a unique green photoluminescence with a quantum yield of 5.4%. The Gd-CDs exhibited a low cytotoxicity and could optically label the C6 glioma cells. Meanwhile, the r(1) relaxivity of Gd-CDs was measured to be 11.356 mM(-1) s(-1). This high r(1) value together with the r(2)/r(1) ratio close to 1 nominates Gd-CDs as an excellent T-1 contrast agent for magnetic resonance imaging. These Gd-CDs combining two complementary imaging modalities are therefore a promising bimodal nanoprobe in medical imaging for a better diagnosis.

在医学成像中，多模态纳米探针的开发是非常必要的，因为它整合了多种成像模式的优势。在本研究中，通过简单的一步微波辅助多元醇法制备了钆掺杂的绿色发光碳点（Gd - CDs）。所获得的Gd - CDs发出独特的绿色光致发光，量子产率为5.4%。Gd - CDs表现出低细胞毒性，并且能够对C6胶质瘤细胞进行光学标记。同时，测得Gd - CDs的r(1)弛豫率为11.356 mM⁻¹ s⁻¹。这个高的r(1)值以及接近1的r(2)/r(1)比值使Gd - CDs成为一种用于磁共振成像的优秀T - 1造影剂。因此，这些结合了两种互补成像模式的Gd - CDs在医学成像中是一种有前景的双模态纳米探针，有助于更好地诊断。