In-vivo Screening of Analgesic and Antiulcer Activity on Carum carvi Seeds

The present study was designed to investigate the antiulcer and analgesic potential of Carum carvi seeds. caraway seeds use is common in diet, so there is no need for special administration of the drug and by little increase in intake quantity, the use of analgesics is abolished. Antiulcer activity was also evaluated by aspirin induced ulcer models. Effect of concurrent administration of ethanolic and aqueous extracts of seeds extract Carum carvi at a dose of 100 and 200 mg/kg b.w. respectively was given by oral route. Ethanolic and aqueous extracts of Carum carvi seeds significantly reduction in gastric content, total acidity, ulcer index, and increase in pH of gastric pylorus ligation ulcer model. In comparison with the standard drug, the results of hydro alcoholic extract at 100 mg dose showed good analgesic and at 200 mg dose showed antiulcer activity compared with a standard drug. Extracts of Carum carvi may be useful as a natural analgesic in the treatment of ulcer, inflammation, and pain.

本研究旨在探讨葛缕子种子的抗溃疡和镇痛潜力。葛缕子种子在饮食中普遍使用，所以不需要特殊给药，只需稍微增加摄入量，就可以不用镇痛药。还通过阿司匹林诱导的溃疡模型评估了抗溃疡活性。分别以100和200毫克/千克体重的剂量口服给予葛缕子种子的乙醇提取物和水提取物。葛缕子种子的乙醇提取物和水提取物在幽门结扎溃疡模型中显著降低胃内容物、总酸度和溃疡指数，并提高胃内pH值。与标准药物相比，100毫克剂量的醇水提取物显示出良好的镇痛效果，200毫克剂量的醇水提取物显示出抗溃疡活性。葛缕子提取物可能作为一种天然镇痛药用于治疗溃疡、炎症和疼痛。