炎症小体介导细胞焦亡和自噬的相关研究

Inflammasomes are large multi-protein complexes, and their activation is involved in the pathological processes of various autoinflammatory and autoimmune diseases. The inflammasome pathway mediated by caspase-1 is activated by pathogenic microorganisms and sterile stressors, and secretes pro-inflammatory cytokines IL-1β and IL-18, which are widely involved in the progression of various chronic diseases, such as atherosclerosis, type 2 diabetes, Alzheimer's disease and arthritis, etc. At the molecular biological level, various inflammasomes play an important role in maintaining the body's autoimmune function and regulating pyroptosis and autophagy.

炎症小体是大型多蛋白复合物,其激活参与各种自身炎症和自身免疫性疾病病理过程。半胱天冬酶1(caspase-1)介导的炎症小体通路受病原微生物和无菌应激物激活,分泌促炎细胞因子IL-1β和IL-18,广泛参与各种慢性疾病的进展,如动脉粥样硬化、2型糖尿病、阿尔兹海默病以及关节炎等。在分子生物学层面,各类炎症小体则在维持机体自身免疫功能和调节细胞焦亡自噬方面发挥重要作用。