Resequencing and association analysis of MIR137 with schizophrenia in a Japanese population

MicroRNA may play a role in the pathophysiology of schizophrenia. A recent meta-analysis of genome-wide association studies indicated a significant association between schizophrenia and a common intronic variation in MIR137HG (microRNA 137 host gene) encoding the primary microRNA-137. To explore additional risk variations for schizophrenia, we resequenced MIR137 and performed an association analysis in 1321 Japanese individuals. By resequencing, we detected four sequence variations in the 5' and 3' flanking regions. There were no significant associations between these variations and schizophrenia. Our resequencing and association analysis of MIR137 failed to find additional risk variations for schizophrenia.

微小RNA可能在精神分裂症的病理生理学中起作用。最近一项对全基因组关联研究的荟萃分析表明，精神分裂症与编码初级微小RNA - 137的MIR137HG（微小RNA 137宿主基因）的一个常见内含子变异之间存在显著关联。为了探索精神分裂症的其他风险变异，我们对MIR137进行了重测序，并在1321名日本个体中进行了关联分析。通过重测序，我们在5'和3'侧翼区域检测到四个序列变异。这些变异与精神分裂症之间没有显著关联。我们对MIR137的重测序和关联分析未能发现精神分裂症的其他风险变异。