Emerging translational therapies for mesothelioma.

Malignant pleural mesothelioma remains a therapeutic and diagnostic problem. Translational mechanisms for treatment of the disease are emerging from newly learned characteristics of the tumor on a molecular, cellular, and extracellular basis. Although slow to reach the clinical arena, these potential strategies do show proof of principle in the in vitro and in vivo settings, and some, including adenoviral molecular chemotherapy, have completed phase I testing. This review describes the rationale and status of these newer treatment ideas.

恶性胸膜间皮瘤仍然是一个治疗和诊断难题。在分子、细胞和细胞外基础上对肿瘤新了解到的特性正在催生该疾病的转化治疗机制。尽管这些潜在策略进入临床应用的进程缓慢，但它们在体外和体内环境中确实显示出了原理验证，并且一些策略，包括腺病毒分子化疗，已经完成了I期试验。这篇综述描述了这些新的治疗思路的原理和现状。