基于导光金属毛细管的便携式、高灵敏度光度计研究

Photometry is widely used for trace analysis in life science, food safety and environmental monitoring, owning to its fast speed analysis and ease of use. This project will investigate the novel nonlinear optical-path enhancement effect in metal-waveguide-capillary (MWC), which can break the restriction of physical length on optical-path. Thus, enhancing the detection sensitivity and resolving the problems of gas bubble trapping and light leaking can be realized. In addition, investigation on combination of Au nano-particles and MWC will be carried out for observing the novel LSPR effects and realizing high sensitive detection of molecule absorption process. Finally, a portable photometry with high sensitive, high selective and ease of use would be realized.

光度计是检测微量物质含量的主要仪器之一，具有快速检测和使用简便等优点，在生命科学、食品安全与环境监测中有着广泛应用。本项目拟开展以下研究：1. 探索导光金属毛细管（MWC）中特有的非线性光程效应，从而打破物理长度对有效光程的制约、提高检测灵敏度、并解决现有导光毛细管中的气泡与光泄露等问题；2. 探索纳米金颗粒与MWC的有机结合方式，研究金属管内纳米金的局域表面等离子共振（LSPR）效应，实现对生物分子等被测物质的特异性吸附、富集、以及高灵敏度检测；3. 在此基础上研制便携式、高灵敏度、高选择性、以及操作简易的光度计。