猪日粮代谢葡萄糖/代谢生脂物质适宜比例的研究

Metabolic lipogenic substance (MLs) refers to the lipids that can be metabolized to synthesize fat after absorption (converted into total acetic acid), including fat absorbed through small intestine and the VFA produced in large intestine (mainly acetic and butyric acids). Considering the central role of glucose on energy utilization in animal, the fat and amino acids would be mobilized to generate the glucose while it is not provided adequately. Recent studies have showed that variations in dietary starch and fiber could affect the VFA production in large intestine and fat utilization in PDV tissues, highlighting the exist of glucose and fat during absorption. Therefore, the project is going to investigate the effect of different levels of dietary metabolic glucose on fat digestion in small intestine, VFA production in large intestine and VFA utilization in PDV tissues, with a purpose to disclose the interaction between metabolic glucose and metabolic lipogenic substances during the digestion and absorption. Our results hold promise in promoting appropriate composition while formulating the pig diets and reasonable exploration of feed ingredients.

代谢生脂物质（MLs）是指日粮经动物消化吸收后产生的可利用的生脂物质（折合成乙酸总量），包括小肠吸收的脂肪和大肠产生的乙酸、丁酸。葡萄糖在动物能量代谢中处于中心地位，当其缺乏时猪会动员脂肪和生糖氨基酸供能而降低能量利用效率。因此，确定猪的代谢葡萄糖和代谢生脂物质需要量以及其适宜比例，对于日粮配制具有重要意义。研究表明，日粮葡萄糖前体物质的变化会影响猪大肠VFA的产生量和门静脉回流内脏（PDV）组织的脂类物质流量，说明代谢葡萄糖和代谢生脂物质之间在养分利用方面存在互作。本项目拟应用消化道瘘管技术、血管瘘技术和同位素示踪技术，系统研究不同日粮代谢葡萄糖水平条件下猪的小肠脂肪消化率、大肠VFA产生量和PDV组织VFA利用量，揭示代谢葡萄糖和代谢生脂物质的互作规律及其对生长性能和脂肪沉积的影响机制，为通过调节日粮代谢葡萄糖和代谢生脂物质调控猪生产性能提供技术方法与理论依据。