改性甲壳素环境敏感水凝胶的结构与其抗菌性能的构效关系研究

Antibacterial material is one of the hot research fields on the functional polymer materials. As a special polymer material, the antibacterial properties of environment sensitive hydrogel also follow some rules of the ordinary polymer materials, but the crosslinking structure will directly cause fundamental changes of some properties, such as the environment in the hydrogel(for example: ion concerntrations and nutrient) and the local concentrations of some groups. It is obviously different from the antibacterial behaviors of the solution and solid. So it has important theoretical and practical significances on the antibacterial property research of the environment sensitive hydrogels. Chitin derivative is a kind of polymer material that can also be used in the antibacterial field. This project is the research on the antibacterial properties and antibacterial mechanism of the environment sensitive hydrogels base on the modified chitin, which aims at revealing the structure-activity relationship on their structures and antibacterial properties. By changing the structure (molecular structure and hydrogel structure) of chitin derivatives, the system research of the antimicrobial effects of the hydrogels and their influencing factors will be investigated. The structure changes of the derivatives and the hydrogels during the environment sensitive couse were analyzed by the modern structure characterization methods. And combined with their swelling dynamics and antibacterial properties, the effects of structure on the antibacterial behavior are analyzed. This project will provide scientific basis for revealing the structure-activity relationship on the structure and antibacterial properties of the environment sensitive hydrogels based on the modified chitin, and it will create the ideas and methods on the research of the structure-activity relationship on the structure and antibacterial properties of the hydrogels.

抗菌材料是功能高分子材料研究热点领域之一。环境敏感水凝胶作为一种特殊的高分子材料，其抗菌性能虽然也遵循普通高分子材料的某些规律，但其交联结构和环境响应性将直接导致凝胶内环境（如：离子浓度和营养物质）和基团局部浓度等性质发生根本变化，明显有别于溶液和固态的抗菌行为，因此，对于环境敏感水凝胶抗菌特性的研究具有重要的理论和现实意义。甲壳素衍生物是一类有望应用于抗菌领域的高分子。本项目拟研究改性甲壳素环境敏感水凝胶的抗菌特性及抗菌机理，旨在揭示其结构与抗菌性能的构效关系。通过改变甲壳素衍生物水凝胶的结构（分子结构和凝胶结构），系统研究水凝胶的抗菌性能及其影响因素。采用现代结构表征的方法研究刺激响应过程中水凝胶的结构变化，并结合溶胀动力学和抗菌性能，分析结构对抗菌行为的影响。本项目为揭示改性甲壳素环境敏感水凝胶的结构与抗菌性能的构效关系提供科学依据，并建立凝胶结构与抗菌性能构效关系的研究思路和方法。