基于金纳米组装结构的磁响应动态增强光声成像对比剂的制备表征及应用前研究

Active tuning of optical properties of plasmonic nanomaterials is regarded as one of the important topics in the research field of stimuli-responsive materials. It is attracting growing research interests as it shows great prospects for the development of new techniques in applications including optical spectroscopy-based chemical/biological sensing and different types of optical imaging. Since one-dimensional assembly of plasmonic nanomaterials into chain-like structures can induce near-field coupling between adjacent particles and produce new optical properties, manipulation of the 1D assembly process in reversible manners is believed to be an effective pathway for active plasmon tuning. Herein, it is proposed by development of novel colloidal synthesis and surface modification strategies, plasmonic gold nanoparticles can be reversibly assembled by application of external magnetic field. Consequently, optical properties of gold nanostructures can be actively controlled by reversible tuning of plasmon coupling. It is believed this type of magnetically-activatable nanomaterials is capable to serve as contrast agent for photoacoustic imaging which possess the property of dynamic contrast enhancement. By carrying out this project, it is expected new strategies for active optical tuning can be developed. Meanwhile, the newly developed materials is expected to deliver benefits to clinical imaging applications as well.

动态调控具有局域表面等离子体共振特性（LSPR）的纳米材料的光学性能是近年来外场响应型胶体体系研究的一个重要内容，其在光谱学检测、生物成像等领域有良好的应用前景。其中，由于LSPR的近场耦合作用，控制LSPR纳米材料的一维可逆组装可有效调控其光学性能。在本项目中，申请人将通过一系列溶液合成、表面修饰等手段研究磁场诱导金纳米结构的一维可逆组装的方法，以实现金纳米材料光学性能动态可调。同时，申请人预期并将通过实验验证这种光学性能随磁响应变化的材料可在光声成像中作为一种新型对比剂并实现传统对比剂不具有的动态对比增强性能。申请人相信，本项目的研究将为动态调控材料光学性能提供新方法，新研制的材料在影像医学中则会有良好的应用前景。

动态调控等离激元纳米结构的光学性能外场响应型胶体体系研究的一个重要内容，其在光谱学检测、生物成像等领域有良好的应用前景。基于此背景，本项目系统研究了磁场调控等离激元纳米结构光学性能的方法及上述体系作为动态增强光声、OCT成像对比剂的性能。通过本项目的研究，研究者发展了“刻蚀-再沉积”等方法调控各向异性超顺磁氧化铁纳米粒子结构的方法，明确了其结构与磁共振成像的构效关系；发展了磁-金复合一维纳米链的制备及其结构调控方法，实现了上述结构的磁响应光学性能调控，验证了其作为磁响应动态增强光声成像、OCT成像对比剂的可行性；研究过程中，研究者还发现了纳米粒子溶液定向自组装的新机制、新理论与新方法。研究者相信，本项目研究获得的磁性动态增强对比剂技术有助于将光声、OCT成像的应用范围拓展到颅内、胰脏等皮下较深部位，对疾病诊疗有潜在应用价值；此外，研究者发展的纳米粒子溶液定向自组装相关理论与方法对自下而上设计制备光学性质可调的等离激元超结构、超材料，设计制备新一代交互式智能响应胶体体系提供了理论与技术支撑，对光学隐身材料等国防科技的研发提供了技术储备。

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