微纳米多尺度钛/碳复合结构的血液相容性及生物物理评价体系研究

By using the liquid laser etching technique (LAL), combined with semiconductor micro patterning process and ion implantation technology, the micro-nano multi-scale Ti/TiC/ta-C gradient composite coating structure were developed in titanium alloy, the key technology problems of the mechanical and anticoagulant properties between titanium and carbon were solved synchronously; Research on assemble of nanometer materials to the micron pattern of titanium alloy substrate by bottom to up method, through the growth of nano- line or network structure on the micrometer patterns, research of micrometer pattern structure, size and nanoline scale and density on the plasma protein adsorption selectivity, improve albumin selective adsorption model of coagulation occurred at first stage; assemble nano carbon in the micro patterns materials, study "electron transfer model" of coagulation occurred in second stages and biophysical model of the blood compatibility, provides the theory basis and the key to solve the technology problems of clinical application for the new anti coagulation materials; calculated by the blood compatibility of the series the experimental and biological physical model, optimization and verification of the micro nano structure and anticoagulant properties, the establishment of animal Model and animal experiment, proposing the evaluation key indexes of blood compatibility and establish a system of evaluation system

采用液体环境激光刻蚀技术(LAL)，结合半导体微图形化工艺和离子注入技术，在钛合金上研制微纳多尺度Ti/TiC/ta-C梯度复合涂层结构，同时解决钛/碳之间机械力学和抗凝血性能的关键技术问题；研究在微米级钛合金图案基体上至底向上组装纳米材料，通过在微米级图形上定位生长纳米(线)或网状结构，研究微米级图案结构、尺寸以及纳米(线)尺度和密度对血浆蛋白选择性吸附，完善凝血发生第一阶段的白蛋白选择吸附模型；结合LAL微纳加工在图案精细定位和纳米组装的优势，实现在纳米线阵列上原位组装C纳米材料，研究包括凝血发生第二阶段的"电子转移模型"在内的血液相容性生物物理模型，为研发新型抗凝血材料提供理论依据和解决临床应用的关键工艺问题；通过血液相容性的系列实验及生物物理模型的计算，优化和验证其微纳结构及其抗凝血性能，建立动物模型并完成动物试验，提出血液相容性材料关键评价指标并建立较系统的评价体系。