建立严重意识障碍患者临床意识检测体系

The destination of the study is to evaluate the residual brain function and its recovery in patients with severe disorders of consciousness (DOC， including coma, vegetative state, minimally conscious state and locked-in syndrome) with behavioural scales, multimodal neuroimaging (including FDG-PET, structure MRI, fMRI)and electrophysiology(including high density EEG and ERP and TMS-EEG). We hope to find the fundation of brain structure and function in consciousness alteration and behavioural fragment,which can increase the efficacy of accurate dignosis and prognosis in this challenging field,meanwhile provide important data for the investigation of the neural correlates of consciousness and behavioral fragments.The significance of this study has three aspects: 1.The results can provide part answer for the worldwide attractive problem - the diagnosis and prognosis of the DOC; 2. It's a unique way to investigate the neural correlates of consciousness through detecting the brian function in DOC; 3.To give new scientific explanation for the DOC.

本研究采用意识行为量表结合多模态神经影像技术（包括FDG-PET、结构和功能磁共振成像）和电生理技术（包括高密度脑电图（EEG）、事件相关电位（ERP）和经颅磁刺激（TMS-EEG））对严重意识障碍（DOC，包括昏迷、植物状态、最小意识状态和闭锁综合症）患者的残余脑功能及其恢复情况展开跟踪检测。本研究的目的是希望找出这类患者意识改变和行为片段的脑结构和脑功能基础，从而提高诊断和预后预测的准确性并为寻找意识和行为片段的神经相关物提供重要数据。本研究的重要性体现在以下三个方面：1）为严重意识障碍的诊治和预后预测这个国际瞩目的医学难题提供部分答案；2）探索意识障碍患者的脑功能是研究意识相关物的一个独特途径；3）对意识障碍形成新的科学解释。