超小Keggin型多金属氧酸盐纳米粒子的制备及CT/光声双模态成像指导的胰腺癌光热治疗研究

Accurate theranostics has recently attracted tremendous attention for pancreatic cancer treatment and become a difficult point and hot issue of biomedical domain, nano theranostic agents can integrate the cancer diagnosis and therapy, providing a new multi-functional platform for early diagnosis and accurate treatment of pancreatic cancer. This project puts forward a concept by using a single component material to accomplish multi-function, and also can be metabolized easily. This material is based on the ultra-small Keggin type polyoxometalate nanoparticles, it can show excellent local surface plasmon resonance characteristics and have strong attenuation ability to X-ray and high absorptance in the near infrared region, through the simple chemical reduction method, a novel nano theranostic agents with pancreatic cancer bimodal imaging and photothermal therapy has been developed. Compared with the reported nano theranostic agents, ultra-small Keggin type polyoxometalate nanoparticles have dual advantages: (1) Single species can realize multiple diagnosis and treatment and solve the defects of complex system interference, (2) It can be rapidly metabolized and improve the clinical safety of nanomaterials.

胰腺癌的精准诊疗是生物医学领域的难点与研究热点，纳米诊疗剂能够将诊断与治疗功能融为一体，为胰腺癌早期诊断与精准治疗提供了一个全新的多功能诊治平台。本项目提出了使用可代谢的单一组分材料实现多重功能的概念，以超小Keggin型多金属氧酸盐纳米粒子为基础材料，充分发挥其优异的局域表面等离子体共振特性、对X射线具有较强的衰减能力以及在近红外区具有吸收的性质，通过简单的化学还原法，得到了集胰腺癌双模态成像与光热治疗于一体的纳米诊疗剂。与已报道的纳米诊疗剂相比，超小Keggin型多金属氧酸盐纳米粒子具有双重优点：（1）单一物种实现多重诊疗，解决复杂体系干扰的缺陷；（2）可快速代谢，提高纳米材料的临床安全性。

胰腺癌的精准诊疗是生物医学领域的难点与研究热点，纳米诊疗剂能够将诊断与治疗功能融为一体，为胰腺癌早期诊断与精准治疗提供了一个全新的多功能诊治平台。本项目提出了使用可代谢的单一组分材料实现多重功能的概念，以超小Keggin型多金属氧酸盐纳米粒子为基础材料，充分发挥其优异的局域表面等离子体共振特性、对X射线具有较强的衰减能力以及在近红外区具有吸收的性质，通过简单的化学还原法，得到了集胰腺癌双模态成像与光热治疗与一体的纳米诊疗剂。与已报道的纳米诊疗剂相比，超小Keggin型多金属氧酸盐纳米粒子具有双重优点：（1）单一物种实现多重诊疗，解决复杂体系干扰的缺陷；（2）可快速代谢，提高纳米材料的临床安全性。在此青年基金资助下，共发表项目号（51902047）标注的SCI论文24篇，申请国家发明专利2项，指导硕士研究生13名（毕业5名，在读8名）。

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