动态力学行为对肺组织细胞结构和生物学功能的影响

Impact load events during peacetime or wartime causes severe soft tissue damage, especially lungs. Since the effect could be life threatening, it is essential to test the dynamic mechanical properties of lung tissue and come up with a constitutive model. It is also essential to discuss, from an organ level and a cellular level, the difference pattern of stress propagation within organisms as well as the mechanisms and effect of stress on tissue structure and biological functions. This project intends to study the experimental techniques of miniature low impedance split-Hopkins pressure bar that can measure the dynamic mechanical properties of lung tissue and the dynamic mechanical properties of lung tissue under different stress loads. We intend to study the mechanical properties of strain rate and its dependence on stress rate. We also intend to utilize high speed cameras to study the static dynamic deformation mode under uniaxial stress, confirm its viscoelastic constitutive model, and utilize cellular and molecular biology techniques to further confirm the mechanisms and effects of stress on tissue structure and biological functions. This is done so that we could provide support on the theory and methods of body protection systems as well as the simulation assessment of the body tissue’s impact loading.

平时或战时等涉及冲击载荷的事件给人体软组织尤其是肺脏造成严重伤害，甚至危及生命，故很有必要对肺脏组织动态力学性能进行测试并确定其本构模型，并从器官水平、细胞水平进一步探讨不同应力在生物体内的传播规律、以及应力对组织细胞结构和生物学功能的影响及其机制。本项目拟研究一套能够测定肺脏组织材料动态力学性能的微型低阻抗分离式霍普金森压杆（SHPB）实验技术，测试肺脏组织材料在不同应力状态下的动态力学性能，研究其力学性能对应变率以及对应力状态的依赖性，并利用超高速摄像机研究其单轴应力状态下的静、动态变形模式，确定其粘弹性本构模型，同时运用细胞生物学和分子生物学技术进一步明确应力对组织细胞结构和生物学功能的影响及其机制。为人体组织在冲击载荷作用下的模拟评估和人体防护系统的设计提供理论和方法上的支撑。