基于三氯甲基化反应的碳一官能化研究

Trichoromethyl group is abundant in natural products and can be converted to diverse one-carbon functional groups, including methyl, choromethyl, dichoromethyl, trifluoromethyl, carboxyl etc. Trichoromethylations of hydrocarbons, halogenerated hydrocarbons and alkyl/aryl boric acids through transition metal-catalyzed cross-coupling or C-H activation reactions to construct C-CCl3 bonds have been drawn up in this project. Meanwhile, derivations of trichoromethyl group to methyl, aldehyde group, ester and amide under milder conditions will be further investigated to develop trichoromethylation reactions into reliable synthetic methods for introducing diverse one-carbon functional groups.

三氯甲基在天然产物中普遍存在，而且可以转化为甲基、一氯甲基、二氯甲基、三氟甲基、羧基等多种碳一官能团。本项目拟通过过渡金属催化的交叉偶联反应和C-H活化反应实现烃、卤代烃、烷基或芳基硼酸（酯）的三氯甲基化反应，构建C-CCl3键。同时，进一步对三氯甲基在更温和条件下转化为甲基、醛基、酯基、酰胺等官能团进行探索，将三氯甲基化反应发展成为引入多种碳一官能团的成熟的合成方法。