免疫效应对HIV感染进程影响的病毒动力学研究

Immune effects play an important role in the process of HIV infection, and different mechanisms of immune effects play different roles. This project will construct HIV dynamics model with immune saturation effect, with CTL lysis and nonlytic immune response model, with immune delay, respectively, then study the global behavior of the model by dynamic system theory and numerical simulation method, and explore the threshold condition of persistence and the ultimate elimination. Through the study of model dynamics, we find and reveal the effect and influence of different immune mechanisms on HIV infection process, quantitatively understand the different immune effects in HIV infection from a holistic and dynamic point of view, expand our understanding of HIV infection and its immune response, so as to explain the infection mechanism of HIV dynamics, characterize the characteristics of HIV dynamics, and compare whether there is immune saturation or not. The influence of the effect on the model and how to retain and restore the immune mechanism in order to eliminate the virus are discussed. The simulation is carried out based on the actual data, which provides a theoretical basis and guidance for the development of new drugs and the formulation of the optimal treatment plan.

免疫效应在HIV感染进程中发挥着重要作用，并且不同的免疫效应机制对HIV感染进程的作用不同。本项目将根据HIV感染的免疫机制，分别建立基于免疫饱和效应的HIV动力学模型，CTL溶细胞和非溶(nonlytic)细胞效应模型，免疫饱和效应下的免疫时滞模型，利用动力系统理论和数值模拟方法研究模型的全局性态，并探索确定艾滋病病毒最终消除和永久持续生存的阈值条件。通过对模型动力学的研究，发现和揭示不同免疫效应机制对HIV感染进程的作用和影响，从整体和动态的角度定量认识HIV感染中的不同免疫效应，拓展我们对HIV感染及其免疫应答的理解，从而来解释HIV动力学的感染机制，刻画HIV动力学的感染特点；对比有无免疫饱和效应对模型的影响，并探讨如何保留和重新恢复免疫机制才能清除病毒，并结合实际数据，进行仿真模拟，从而为研发新药和制定最优的治疗方案提供了一定的理论基础和指导作用。