数学与系统生物学交叉研究平台

This project continues the effort we planed in the previous proposal approved in 2015. The major aim has been to develop an international research center on mathematical biology, building up from the research team at Guangzhou University as a core, partnering with Guangzhou Center for Disease Prevention and Control, and Michigan State University in the United States. The center will operate as a research platform to serve the colleagues and students in China, emphasizing in particular the South China. The research topics will be focused on systems biology, stochastic gene expression, and prevention and control of dangerous diseases such as dengue fever, malaria, and Zika. We will integrate and optimize the resources in the universities and research institutions in Guangdong and neighboring provinces, to promote innovative ideas and knowledge exchange, to work jointly on the problems in the emergent need of medical science and for the advancement of mathematical theory. Because of our promising progress in dengue control, the applicant was invited by the organizing committee in the IAEA meeting for monitoring dengue virus in Southeast Asia to deliver a plenary talk. In the forthcoming years, we will continue to uphold our main idea of "freedom, integration and social services", to attract more talented researchers in mathematics, computer sciences, biology, and medical sciences, to carry out a series of academic activities. We will also extend our interdisciplinary studies to cooperate with medical institutions or hospitals on microbiology, chronic respiratory disease and HIV. The platform is expected to help make major scientific and technological achievements, encourage the growth of young talents, and advance the creativity, originality, and independent innovation of Chinese sciences in mathematics, biology and medical sciences.

本项目是上年度平台建设项目的延续。自立项以来，我们开始筹建以广州大学生物数学团队为核心，以广州市疾病防控中心及美国密歇根州立大学为主要合作伙伴的国际生物数学研究中心。该中心服务华南，辐射全国，以基因表达的随机调控、登革热和疟疾防控等问题为突破口，优化整合资源，推动知识的创新和现实问题的解决。其中鉴于项目组在登革热防控研究的进展，申请人于今年 3月受邀参加国际原子能机构“南亚与东南亚监控登革病毒媒介”国家顾问会议并做大会报告。在新的年度，我们继续秉承“自由、融合及服务社会”的发展思路，聚合数学、生物医学及计算机等领域卓越人才开展一系列学术活动，联合进行课题攻关，促进跨学科合作研究；保持原有交叉融合基础，拓展与微生物，呼吸道慢性病和HIV研究专家的合作，加强研究针对性和原创性。该研究平台的发展将有利于实现培育重大科技成果和培养优秀科研人才的有机结合，提升我国数学、生物及医学科技自主创新能力。

本项目是2016年度平台建设项目的延续。在广州市政府及广州大学的支持下，我们建立了“广州大学应用数学研究中心”。本年度，我们继续秉承“自由、融合及服务社会”的发展思路，联合数学、生物医学及计算机等领域卓越人才开展学术活动。我们引进了美国的Wieslaw Krawcewicz教授和李佳教授等高层次人才，主办学术会议4次、专题讲习班2次，邀请国内外专家交流访问30余人次，参加学术会议100余人次，境外访学9人次，发表科研论文15余篇。通过学术交流活动，以随机基因表达及其调控机制、登革热和疟疾及其它传染病的防控等问题为突破口，我们融合了众多数学家和生物学家进行多学科的交叉研究，同时培养了年轻人才、壮大了研究队伍，针对生物数学交叉研究领域的一些前沿问题，我们取得了一系列成果。本项目的实施为华南，乃至全国的高水平数学与系统生物学交叉学科提供了研究平台，为提升生物数学的整体研究水平做出了一定贡献。综上所述，我们完成了计划书中制定的项目研究目标。

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