基于超分子自组装和TTA上转换发光的手性区分与传感

This project will establish a new supramolecular chiral recognition/sensing strategy by combining the properties of host-guest complexation and triplet-triplet annihilation (TTA) upconverted emission. TTA sensitizer or emitter will be introduced into chiral supramolecular systems, and supramolecular TTA upconverted emission-based chiral discrimination and sensing will be realized by manipulating the intermolecular complexation and the energy transfer through supramolecular assembly. By performing the project, we expect to gain the following development and breakthrough: .1..We will choose cyclodextrins and pillar[n]arenes as chiral molecular hosts and develop the synthetic methods of sensitizer/emitter-modified chiral hosts..2..By reasonably designing the supramolecular aggregation and host-guest complexation, we will get deep insight into the factors that influencing the supramolecular TTA upconverted emission, and therefore establish the theory of upconverted emission of supramolecular self-assembly systems..3..Supramolecular TTA upconverted emission-based chiral discrimination and sensing will be realized though competitive complexation with chiral guests, and a new chiral discrimination and sensing strategy will be established. .4..Highly sensitive and stereoselective chiral sensing is expected to be achieved by optimizing the photophysical properties of sensitizers and emitters and manipulating the chemical structures of hosts and guests and the solvent and temperature conditions.

该项目结合超分子自组装和三线态-三线态湮灭（TTA）上转换发光的特点，将TTA上转换发光敏化剂或发光团导入到手性超分子体系中，利用主客体包结调控敏化剂、发光团和手性客体等组分间的作用和能量传递，建立基于超分子TTA上转换发光的手性传感体系。并在以下几方面获得进展和突破: 1. 选用环糊精和柱芳烃为主体分子，开发出TTA上转换发光响应基团修饰的手性主体的化学合成方法。2.合理设计超分子聚集和主客体作用，研究调控超分子TTA上转换发光的因素和机理，建立通过超分子自组装调控上转换发光的理论。3.利用手性分子的竞争包结对超分子体系TTA上转换发光的调控作用实现手性区分和传感，建立超分子TTA上转换发光手性区分和传感新策略。4.通过优化敏化剂、发光团的光物理性质，调整主客体分子结构、溶剂以及温度等条件获得高灵敏、高立体选择性手性传感。