具有松质骨类似机械力学性能及多孔结构的明胶-纳米生物活性颗粒复合支架材料

We aim to design gelatin-based composite scaffolds with improved mechanical properties and bioactivities. These scaffolds are prepared through freeze-drying gelatin/bioactive nanoparticle mixture solutions and they will combine the good proccessability and biocompatability of gelatin and osteogenic of silicate-based bioactive particiles. By doing such, we aim to develop materials suitable for cancellous bone defect reparing. We expect that the hydrophilic gelatin scaffold would facilitate the exchange of nutrients and metabolites between the scaffold and surrounding environment, the bioactive nanoparticle would promote cell attachment and growth, while through the strong physical interations between gelatin and nanoparticle, the over swollen of scaffold could be avoided. To test the above hypothesis and achieve the set goal, in this project, we will explore ways to control the interactions between gelatin and nanoparticles, to adjust the microstructure, physicochemical and mechanical properties of the composite scaffolds, and to evaluate the biomedical performance of these scaffolds both in vitro and in vivo. This project will provide new input on the development of bone reparing materials.

针对骨填充材料机械力学性质和生物活性优化设计基于明胶的复合支架材料体系。该材料由生物活性纳米颗粒和明胶的复合溶液通过冷冻干燥制得，综合了明胶良好的生物相容性和加工性以及生物活性纳米颗粒良好的成骨性，期望其能在松质骨缺损修复方面有所应用。我们设想利用多孔明胶支架孔道的亲水性方便营养物质和代谢产物的快速输运，借助生物活性纳米颗粒的活性帮助细胞快速黏附、增殖，同时通过纳米颗粒与明胶分子之间的强物理相互作用避免亲水性支架的过度溶胀。为了验证以上思想及达到设定的目标，本项目中我们主要将探索明胶与纳米颗粒之间相互作用的调控、复合支架结构与性能的调控以及复合支架生物医用性能的评价，从而为发展新型骨填充材料提供新思路。

针对骨填充材料机械力学性质和生物活性优化设计基于明胶的复合支架材料体系。该材料由生物活性纳米颗粒和明胶的复合溶液通过冷冻干燥制得，综合了明胶良好的生物相容性和加工性以及生物活性纳米颗粒良好的成骨性，期望其能在松质骨缺损修复方面有所应用。我们设想利用多孔明胶支架孔道的亲水性方便营养物质和代谢产物的快速输运，借助生物活性纳米颗粒的活性帮助细胞快速黏附、增殖，同时通过纳米颗粒与明胶分子之间的强物理相互作用避免亲水性支架的过度溶胀。为了验证以上思想及达到设定的目标，本项目中我们主要探索明胶与纳米颗粒之间相互作用的调控、复合支架结构与性能的调控以及复合支架生物医用性能的评价，从而为发展新型骨填充材料提供新思路。研究发现，具有高比表面积的纳米生物活性颗粒的体外活性与细胞增殖效果更好，其与明胶组成的复合支架具有与松质骨相似的孔隙率和机械性能，在体外显示出优异的生物活性和促进成骨细胞增殖的性能。应用在大鼠股骨临界缺损模型中，发现5mm的骨缺损在12周几乎完全愈合，因此，这种复合支架可能成为临床大段骨缺损修复的潜在骨植入物。

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