促进骨愈合的可降解镁合金力-化调控机理研究

This project aims to solve the problems encountered during the bone repairing by magnesium alloy, such as the fast degradation of the alloy, mismatch with bone healing, reduced strength and toughness of the alloy. In order to achieve this goal, the regulation mechanism of mechanical-biochemical coupling signals on biodegradation properties and bioactivity will be explored for ZEK100 magnesium alloy in this project. The effect of preload on the deformation mechanism and fatigue properties of ZEK100 alloy during the process of biodegradation will be investigated first to obtain the Mg alloy with improved mechanical properties. Mechano growth factor (MGF) will be further introduced into the preload-improved ZEK100 alloy by applying layer-by-layer assembly technology. Then the controllability of biodegradation, bioactivity and service life of the MGF-modified ZEK100 alloy will be investigated by the vivo and vitro experiments, and the effect of MGF on bone healing will be analyzed. Based on the prior results, a fatigue life model will be established to predict the biodegradation-affected life of MGF-modified ZEK100 alloy in vivo conditions. Finally, the influence of preload and MGF-layer on bone healing and Mg alloy degradation will be concluded and the bone-repairing capability of MGF-modified Mg alloy will be evaluated. The to-be-derived results are important for clinical application of Mg alloys and are able to promote the development of bone medical science and improvement of clinical technology.

本课题通过探讨力学、生化学信号调控镁合金疲劳降解性能及生物活性的机理，旨在解决镁合金修复骨缺损所面临的降解速度过快、与骨愈合不匹配及强韧性低等问题。以ZEK100镁合金为实验对象，研究不同预载荷对降解过程中镁合金的变形机制及疲劳力学性能的影响，获得综合力学性能改善的镁合金材料；基于该材料，采用层层自组装技术，制备力生长因子MGF改性镁合金材料，通过体内和体外实验，研究其降解可控性、生物活性及服役寿命，分析MGF对骨组织愈合的影响机理；建立MGF改性镁合金的疲劳降解寿命预测模型，用于对镁合金植入体内服役寿命的预测。总结预载荷和MGF改性层对骨损伤愈合及镁合金降解的影响规律，进而评价MGF改性镁合金骨修复材料的骨修复能力。此研究对于镁合金的临床应用具有重要价值，可以促进骨的基础医学发展和临床治疗方法的改进。