基于反刍思维为靶点的抑制控制训练干预抑郁症状的效果及脑机制研究

Rumination is a core feature of major depressive disorder, impacting illness onset and relapse. Blocking ruminative thinking is an essential strategy of prevention and treatment of depression. Studies have suggested that inhibitory control deficits would lead individual with high ruminative tendency deepen into rumination. Theoretically, improving individuals’ inhibitory control capacity would block the rumination and relieve depressive symptoms, but up to now, there is no evidence to support that. Our pilot study suggested that after rumination-focused inhibitory control training, ruminative tendency and depressive symptoms were significantly decreased compared with the phase without training. Furthermore, the extent of changes in rumination positively correlated with the extent of changes in depressive symptoms. On the basis of the pilot experiment, current project will explore the efficacy of rumination-focused inhibitory control training on depressive symptoms in individuals with high ruminative tendency. To understand the efficacy, neuroimaging technology with brain connectomic method will be engaged to investigate the neural correlates. Furthermore, patients with major depressive disorder would be recruited to test the clinical value of rumination-focused inhibitory control training. By this project, further knowledge on rehabilitation process of depression and new intervention strategy for depressive disorder will be enriched.

反刍思维是影响抑郁发作及复发的重要风险因素，对其进行矫正是预防和治疗抑郁症的一项重要策略。抑制控制缺陷则是促使个体陷入反刍思维的重要原因。因而，通过提高个体的抑制控制能力矫正反刍思维，进而缓解抑郁症状具有理论可行性，但目前缺乏实证研究支持。为此，本项目在预实验结果提示以反刍思维为靶点抑制控制训练可以降低反刍思维和抑郁症状的基础上，进一步探究该训练方案干预高反刍思维倾向个体的抑郁症状的有效性。为知其所以然，本项目采用神经影像和脑连接组学的方法深入探究抑制控制训练矫正反刍思维进而缓解抑郁症状的脑机制。最后，为明晰以反刍思维为靶点的抑制控制训练干预抑郁症状的临床适用性，本项目以抑郁症患者为研究对象，探究结合药物治疗与抑制控制训练对抑郁症患者的抑郁症状的干预效果。通过本项目的开展，不仅可以促进对抑郁症康复机理的认知，还可以为抑郁症的预防和干预提供新的方法，具有重要的学术价值和临床实践意义。

反刍思维是个体罹患抑郁症和抑郁症复发的重要风险因素,而抑制控制缺陷是反刍思维诱发的重要原因.为此本项目以反刍思维为靶点的抑制控制训练干预抑郁的效果，并采用神经影像技术探究以反刍思维为靶点的抑制控制训练干预抑郁症状的脑神经机制。在项目的执行中，我们主要从五个方面开展：1反刍思维的底层心理学机制------抑制控制缺陷的脑机制；2. 如何评估诱发和评估状态性反刍思维；3. 基于多尺度、多维度的方法有效的降低反刍思维；4.抑郁个体的积极情绪的维持缺陷是否源于认知控制的缺陷；5. 以认知控制促进为起点促进脑健康。针对以上5个方面的内容的开展，本项目揭示了以抑制控制为核心的认知控制缺陷是反刍思维的核心心理学机制，通过认知控制训练可以降低反刍思维，为抑郁症的干预提供了新的视角，基本完成了项目中所设定的任务。与此同时，在研究任务执行的过程中，进一步拓展相关领域的研究，加深了对抑郁的心理病理学的理解，也为后续促进脑健康提供新的见解和思路。

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