言语监控的神经机制研究

Fluent speech needs efficient mechanisms for monitoring and controlling our own production. Most studies investigate the speech monitoring and control mechanism from a perspective of speech production or perception separately. Recently, new theories suggest that motor and perceptual systems are collaboratively contributing to many aspects of cognition. In fact, the core process of speech monitoring and control has been proposed as a motor-to-sensory transformation. However, the underlying neural mechanism of motor-to-sensory transformation in speech monitoring and control is far from clear. In this study, we will use novel speech imagery paradigms in combination with electroencephalography (EEG) and function magnetic resonance imaging (fMRI) to investigate the motor-to-sensory transformation in speech monitoring and control. Furthermore, we will explore the mechanistic relation between the function of speech monitoring and control with auditory hallucination. This investigation will, in general, advance our understanding about how action-perception interaction shapes our cognition, and in specific, reveal the detailed functions of motor-to-sensory transformation in speech monitoring and control, which may facilitate our understanding the mechanisms of speech-related neural disorders, especially auditory hallucination.

监控自我发音对流利说话至关重要。大多数对言语的研究集中从言语产生和言语感知两个方向独立进行，但最新理论提出运动系统及感知系统可以作为一个有机整体考虑。研究表明，言语监控的核心过程正是运动感知转换机制，但其功能特性还不清楚。结合创新的想象发音行为实验范式和脑电及功能性磁共振等认知神经科学试验方法，本项目将在言语领域重点探索运动感知转换机制，进而更全面理解言语监控功能及其神经机制，并在此基础上进一步探索言语监控机制与幻听的关系。本项研究不仅可以进一步揭示运动、感知系统是如何相互作用来影响认知功能，而且可以探索运动感知转换在言语与语言这个特定领域中的功能及作用，进而帮助我们理解言语相关神经紊乱尤其是幻听等疾病的机制。

监控自我发音对流利说话至关重要。大多数对言语的研究集中从言语产生和言语感知两个方向独立进行，但最新理论提出运动系统及感知系统可以作为一个有机整体考虑。研究表明，言语监控的核心过程正是运动感知转换机制，但其功能特性还不清楚。结合创新的想象发音和发音准备实验范式和脑电磁图及功能性磁共振等认知神经科学试验方法，本项目在言语领域重点探索运动感知转换机制，进而更全面的理解了言语监控功能及其神经机制，并在此基础上进一步探索了言语监控机制与幻听的关系。本项研究进一步揭示了运动、感知系统是如何相互作用来影响认知功能，探索了运动感知转换在言语与语言这个特定领域中的功能及作用，帮助我们理解言语相关神经紊乱尤其是幻听等疾病的机制。

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