肠道微生态的调控对炎症性结肠癌的干预

Intestinal microecology is pivotal in the pathogenesis of inflammatory bowel disease (IBD)-associated inflammation-induced colorectal cancer (CRC), yet mechanisms for these effects remain poorly characterized. In this study, we mainly focus on the role of microecology in inflammation-promoting carcinogenesis. And we will explore probiotic bacteria as a promising avenue for therapeutic intervention against CRC. Previously, lactobacillus NS-8 showed great anti-inflammatory and anticarcinogenic activities in vivo and in vitro studies. Here we will investigate molecular mechanisms underlying the efficacy of probiotic bacteria NS-8 in AOM/DSS models of colitis-associated cancer(CAC). Giving the interaction between mucosal innate immune system and microbiota, we will explore regulation of inflammatory cytokines and modification of gut microbial composition in the process of carcinogenesis. Our finding will highlight the importance of intestinal microecology in inflammation-promoting carcinogenesis, and offer fundamental knowledge for development probiotic approaches in the prevention and treatment of inflammation associated diseases.

人体肠道微生态在炎症性结肠癌的发生中起着重要的作用，然而相关机理还知之甚少。因此，从肠道微生态的角度探讨炎症相关的肿瘤发生机制，从干预微生态的角度寻求结肠癌预防或治疗的途径是本课题的关键科学问题。我们在前期研究中已经筛选到具有显著抗炎、抑癌活性的益生菌菌株-NS-8乳酸菌。本课题即在前期基础上，以AOM/DSS小鼠炎症性结肠癌为模型在个体、细胞和分子水平考察NS-8预防或延缓肠炎-癌的转变。在机制研究方面，我们将围绕炎症环境-肠道菌群的相互关系，重点探讨在炎-癌转化过程中肠粘膜先天性免疫系统与肠道菌群的变化情况，以及NS-8乳酸菌对肠道微生态的调控机制。本课题的研究成果不仅有助于从肠道微生态的角度阐释炎症性结肠癌的病理机制，而且可以为开发以益生菌为代表的微生物干预手段在炎症性疾病的预防和治疗中提供理论基础。