Interplay between IL-17-producing pulmonary mucosal tissue-resident memory T-cells (Trm) and regulatory T-cells (Tregs) in HIV/SIV infections: impact on the lungs inflammation.

HIV/SIV 感染中产生 IL-17 的肺粘膜组织驻留记忆 T 细胞 (Trm) 和调节性 T 细胞 (Treg) 之间的相互作用：对肺部炎症的影响。

• 批准号: 493462
• 负责人: Jenabian Mohammad-Ali
• 金额: $ 7.29万
• 依托单位: Universit du Qubec Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-09-01 至 2024-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=493462&lang=en
• 关键词: Copd; Hiv; Il-17; Inflammation; Lungs; Mucosal Immunity; Regulatory T-Cells (Tregs); Siv; Tgf-Beta; Tissue Resident T-Cells; Copd; Hiv; Il-17; Inflammation; Lungs; Mucosal Immunity; Regulatory T-Cells (Tregs); Siv; Tgf-Beta; Tissue Resident T-Cells

Approximately 14% of deaths worldwide are due to lung disease. People living with HIV (PLWH) are at higher risk of lung infections and diseases, even when they take effective antiretroviral therapy (ART). Importantly, we showed a higher quantities of HIV

全世界大约14％的死亡是由于肺部疾病。患有艾滋病毒（PLWH）的患者即使接受有效的抗逆转录病毒疗法（ART），肺部感染和疾病的风险也更高。重要的是，我们显示出更高数量的HIV