Heparan sulfate as a platform to boost regulatory T cell suppression of autoimmunity

硫酸乙酰肝素作为增强调节性 T 细胞抑制自身免疫的平台

• 批准号: 490663
• 负责人: Kuipers Hedwich F
• 金额: $ 61.3万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-09-01 至 2028-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=490663&lang=en
• 关键词: Autoimmunity; Car Technology; Extracellular Matrix; Heparan Sulfate; Heparanase; Hydrogels; Il-2; Neuroinflammation; Regulatory T Cells; T Cell Biology; Autoimmunity; Car Technology; Extracellular Matrix; Heparan Sulfate; Heparanase; Hydrogels; Il-2; Neuroinflammation; Regulatory T Cells; T Cell Biology

In healthy people, immune tolerance (preventing the immune system from attacking its own body) is maintained by specific regulatory immune cells, Treg. In people with autoimmune diseases such as multiple sclerosis (MS), these cells seem unable to maintain

在健康的人中，免疫耐受性（防止免疫系统攻击其自身的身体）由特定的调节免疫细胞Treg维持。在自身免疫性疾病（例如多发性硬化症（MS））的患者中，这些细胞似乎无法维持