Engineering cannabis-loaded hydrogels/emulsions to treat inflammatory tissue diseases

设计大麻负载水凝胶/乳液来治疗炎症组织疾病

• 批准号: 561197-2020
• 负责人: Rouabhia, MahmoudM
• 金额: $ 4.9万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=760608
• 关键词: Engineering; cannabis; loaded; hydrogels; emulsions

Skin and mouth inflammations have a profound and potentially devastating impact on patients' general well-being and self-esteem. It is estimated that skin-related illnesses rank as the fourth most frequent cause of all human diseases, affecting approximately 1.9 billion people at any time (almost one-third of the world's population). In contrast, illnesses of the oral mucosa affect close to 64% of patients. For all skin diseases reported in Canada between 1990 and 2017, disability-adjusted life years increased by 8%, with significant health and economic impacts. Treatment of these inflammatory tissue diseases often involves topical and systemic therapies with some limitations, such as toxicity and other negative outcomes. Medical cannabis products could prove to be a highly promising alternative. The safe delivery of cannabis products is also a challenge. This research project aims to design a cannabis product-loaded biopolymer to deliver cannabis products to prevent and/or cure tissue inflammatory diseases. Two different natural (fibrin and gelatin) and two different synthetic (PVA and PU) polymers will be compared in terms of cannabis product loading and distribution in polymers, delivery profile to human tissues, preservation of the cannabis activities, and the control of tissue inflammation. We intend to develop an easy to produce cannabis products delivery system (DS) in collaboration with a biotech partner. This DS will be easy to use and to cover a large skin surface without adverse effect. The designed DS will be cost-effective to the users and economic benefit to the biotech partner.

皮肤和口腔炎症对患者的一般福祉和自尊心产生深远的毁灭性影响。据估计，与皮肤相关的疾病是所有人类疾病的第四大最常见原因，随时影响约19亿人（几乎占世界人口的三分之一）。相反，口腔粘膜的疾病影响近64％的患者。对于1990年至2017年加拿大报告的所有皮肤疾病，残疾调整的生活年增加了8％，其健康和经济影响重大。这些炎症组织疾病的治疗通常涉及局部和全身性疗法，这些疗法有些局限性，例如毒性和其他负面结果。医用大麻产品可能被证明是一种非常有希望的选择。大麻产品的安全交付也是一个挑战。 该研究项目旨在设计大麻产品的生物聚合物，以提供大麻产品，以预防和/或治愈组织炎症性疾病。将根据聚合物中的大麻产物载荷和分布，对人体组织的递送，保留大麻活性以及组织炎症的控制，将两种不同的天然（纤维蛋白和明胶）和两个不同的合成（PVA和PU）聚合物进行比较。我们打算与生物技术合作伙伴合作开发易于生产的大麻产品输送系统（DS）。该DS易于使用，并且可以覆盖较大的皮肤表面而不会产生不利影响。设计的DS将对用户和生物技术合作伙伴的经济利益具有成本效益。