Deciphering a new mechanism to neutralize fungal resistance to nitrosative stress.

破译一种中和真菌对亚硝化应激的抗性的新机制。

• 批准号: 483820
• 负责人: Labbe Simon
• 金额: $ 7.29万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2024-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=483820&lang=en
• 关键词: Fungal Defense Proteins; Inhibition Of Fungal Flavohemoglobins; Nitric Oxide-Induced Responses; Nitrosative Stress-Resistance

It is well established that fungi protect themselves from nitric oxide (NO), an antimicrobial compound produced and released by macrophages and other immune cells in host defense. Although fungal species have evolved few strategies to detoxify the adverse

众所周知，真菌可以保护自己免受一氧化氮（NO）的侵害，一氧化氮是一种由巨噬细胞和其他免疫细胞在宿主防御中产生和释放的抗菌化合物。尽管真菌物种已经进化出很少的策略来解毒有害物质