Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres

自组装纳米管和纳米球的设计、合成和表征

• 批准号: RGPIN-2017-05409
• 负责人: Dory, Yves
• 金额: $ 2.04万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748670
• 关键词: Design; Synthesis; Characterization; Self; Assembling; Design; Synthesis; Characterization; Self; Assembling

The goal of the program is to obtain several new organic clusters having controlled shapes, tubes and spheres, through predicted self-assembly. The tubular and spherical clusters that we are targeting are held together by means of weak interactions: H-bonds and van der Walls contacts. Most sub-units leading to tubes have C3, Ci and S2 symmetry and are either cyclic peptides made from unusual amino-acids or polyamides of cis geometry. The cyclic peptides sub-units can stack on top of each other to generate wires or tubes having either very strong dipoles like alpha helices or no dipole at all. The other type of sub-units having disk shapes can either form sheets like graphite or balls of T, O or I symmetry, like buckminsterfullerene, that could encapsulate metals and other molecular objects. Supermolecules of these types could have direct applications in many areas of research and technology such as biological transport, drug delivery, sensing, non-linear optics, conductivity, photonics, gels and other new materials, catalysis The program is based on an iterative process involving all the following steps to finally get a complete structure properties relationship chart:Step 1) The sub-units will be carefully designed and their self-assembly will be studied by molecular modelling. Step 2) The synthesis of the sub-units will be carried out in the laboratory.Step 3) Their self-assembly and the properties of the supramolecular architectures will be studied with several modern techniques, like NMR, MS, SEM, TEM, crystallography, etc.Step 4) Analysis of the results will either lead to useful supramolecules (that can be published and/or find applications) or necessitate a fine tuning, in which case the process will be restarted (step 1) with accumulated knowledge.

该程序的目的是通过预测的自组装获得几个具有控制形状，管和球体的新有机簇。我们靶向的管状和球形簇通过弱相互作用将其固定在一起：H键和范德尔壁的触点。导致管子的大多数子单元具有C3，CI和S2对称性，并且是由不寻常的氨基酸制成的环状肽，或者是顺式几何形状的聚酰胺。环状肽子单元可以彼此堆叠，以生成具有非常强的偶极子（如α螺旋​​）或根本没有偶极子的导线或管。 具有磁盘形状的另一种类型的子单元可以形成诸如石墨或t，o或i对称的球（如Buckminsterfullerene）的表，可以封装金属和其他分子对象。这些类型的超级分子可以在许多研究和技术领域中直接应用，例如生物运输，药物输送，传感，非线性光学，电导率，电导率，光子学，凝胶和其他新材料，该程序基于催化程序是基于迭代过程，涉及以下所有步骤，以最终获得完整的结构属性图表：subec subec the Suberem the Suberem and Subermort and Subermort and Subermort and Subsorm and sissem and sissem and sissem and sissem and sissem and sissem。 Step 2) The synthesis of the sub-units will be carried out in the laboratory.Step 3) Their self-assembly and the properties of the supramolecular architectures will be studied with several modern techniques, like NMR, MS, SEM, TEM, crystallography, etc.Step 4) Analysis of the results will either lead to useful supramolecules (that can be published and/or find applications) or necessitate a fine tuning, in which case该过程将以积累的知识重新启动（步骤1）。