A gas chromatography tandem mass spectrometry (GC-MS/MS) system for trace contaminant of emerging concern (TCEC) research

用于新兴关注痕量污染物 (TCEC) 研究的气相色谱串联质谱 (GC-MS/MS) 系统

• 批准号: RTI-2022-00134
• 负责人: Eskicioglu, Cigdem
• 金额: $ 10.93万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=741767
• 关键词: gas; chromatography; tandem; mass; spectrometry

The requested gas chromatography tandem mass spectrometry (GC--MS/MS) system supports an imperative equipment requirement of three Environmental Eng. faculty in the School of Eng. (SoE) at the University of British Columbia (UBC)'s Okanagan Campus (UBCO). The team aims to understand the fate/behaviour of legacy trace contaminants of emerging concern (TCEC; e.g., pharmaceuticals/personal care products, flame retardants, pesticides, dioxins, and furans) and disinfection-by-products (DBPs) in conventional and advanced water and wastewater treatment plant (WWTP) processes. It is vital that they are accurately quantified to comply with regulations under consideration for plant effluent and biosolids streams for expansions and new treatment facilities. Timing of on-going projects is crucial as Metro Vancouver's Liquid Waste Services Department is developing new plants (i.e., North shore WWTP, Northwest Langley WWTP, Iona Island WWTP) and considering upgrades to the other two existing plants (i.e., new anaerobic digesters at Lulu and Annacis Island WWTPs). This is approaching $4 billion of capital infrastructure investment over the next 15 years, and key decisions can be informed by the findings significantly enhanced through the IRC program and the requested GC-MS/MS. The team urgently needs an advanced GC--MS/MS system with high sensitivity to obtain accurate quantification of chemical, biochemical, and environmental compounds at low limit of quantitation, preferable parts per billion (ppb) or lower as per European Union and North American reporting level of TCEC and DBPs. This is currently impossible with our existing equipment. The equipment will support the training of highly qualified personnel (HQP) and enable the potential projects and partnerships that are out of reach for many industrial and municipal partners due to the unavailability of a GC-MS/MS in the vicinity. The lack of a GC-MS/MS on our campus has resulted in the loss of multiple collaboration opportunities with industrial partners in the Okanagan (e.g., Regional Districts of the North and Central Okanagan, BC First Nations Health Authority) and has caused significant research interruptions, including HQP not being trained and delays to students' graduations and publications. The three co-investigators currently supervise approximately 30 HQP and the training potential of the instrument can be as high as 50 HQP including the researchers in the teams of the potential users within the SoE and the Faculty of Sciences. Having an GC-MS/MS facility on Campus will allow the efficient, repeatable, and timely quantification of nearly all legacy TCEC, DBPs and biochemical compounds (in tandem with existing analytical facilities). The skills gained with this equipment will help HQP to secure jobs in the private and public sector in various engineering and science disciplines dealing with analysis of environmental, biochemical and pharmaceutical samples (e.g. AECOM, Bureau Veritas, ALS Labs).

所需的气相色谱串联质谱 (GC--MS/MS) 系统支持三个环境工程的迫切设备要求。工程学院的教师。 （SoE）在不列颠哥伦比亚大学（UBC）的奥肯那根校区（UBCO）。该团队旨在了解传统和先进技术中新兴关注的遗留微量污染物（TCEC；例如药品/个人护理产品、阻燃剂、杀虫剂、二恶英和呋喃）和消毒副产品（DBP）的命运/行为水和废水处理厂 (WWTP) 流程。至关重要的是，必须对它们进行准确量化，以符合正在考虑的用于扩建和新处理设施的工厂废水和生物固体流的法规。正在进行的项目的时机至关重要，因为大温哥华地区的液体废物服务部正在开发新工厂（即北岸污水处理厂、西北兰利污水处理厂、爱奥纳岛污水处理厂）并考虑升级其他两个现有工厂（即位于露露和安纳西斯岛污水处理厂）。未来 15 年资本基础设施投资将接近 40 亿美元，通过 IRC 计划和所要求的 GC-MS/MS 显着增强的研究结果可以为关键决策提供依据。该团队迫切需要一种具有高灵敏度的先进 GC-MS/MS 系统，以便以低定量限（优选十亿分之一 (ppb) 或更低）对化学、生化和环境化合物进行准确定量（按照欧盟和北美的规定） TCEC 和 DBP 的报告水平。这对于我们现有的设备来说是不可能的。该设备将支持高素质人员 (HQP) 的培训，并实现许多工业和市政合作伙伴由于附近没有 GC-MS/MS 而无法实现的潜在项目和合作伙伴关系。我们校园内缺乏 GC-MS/MS，导致失去与奥肯那根工业合作伙伴（例如，北奥肯那根和中奥肯那根地区、不列颠哥伦比亚省原住民卫生局）的多个合作机会，并引起了重大研究中断，包括总部未接受培训以及学生毕业和出版的延误。三名联合研究人员目前监督大约 30 个 HQP，该仪器的培训潜力可高达 50 个 HQP，其中包括 SoE 和科学院内潜在用户团队的研究人员。校园内拥有 GC-MS/MS 设施，可以对几乎所有传统 TCEC、DBP 和生化化合物进行高效、可重复且及时的定量（与现有分析设施相结合）。通过该设备获得的技能将帮助 HQP 在涉及环境、生化和药物样品分析的各种工程和科学学科（例如 AECOM、必维国际检验集团、ALS 实验室）的私营和公共部门获得工作。