Facing pain is effortful: a multidisciplinary approach to investigate the effects of pain on perception of effort and performance

面对疼痛是需要付出努力的：采用多学科方法来研究疼痛对努力和表现的感知的影响

• 批准号: RGPIN-2019-05057
• 负责人: Pageaux, Benjamin
• 金额: $ 2.4万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=738036
• 关键词: Facing; pain; effortful; multidisciplinary; approach

Every day, when we perform voluntary physical and mental tasks, such as climbing the stairs or solving complex puzzle, we perceive effort. The perception of effort is associated with voluntary actions, contributes to the sense of agency, and provides crucial information on the perceived cost of personal actions. Interestingly, while it seems obvious that when we perceive pain the tasks of our everyday life become more effortful (or harder), this assumption has not been investigated. The proposed work uses a multidisciplinary approach to understand how pain impacts performance and the perception of effort during cognitive, physical and dual tasks. The first objective will be to test the hypothesis that the preservation of cognitive and physical performance in the presence of pain is due to an increase in resource allocation that is reflected in an increased perceived effort (subproject 1, performed by undergraduate students supervised by the principal investigator -PI- and mentored by one PhD student). The second objective will be to test the hypothesis that the increased perception of effort in the presence of pain during cognitive and physical performance is associated with alterations in corticospinal excitability (subproject 2, performed by MSc students supervised by the PI). The third objective will be to identify brain networks involved in perception of effort, during cognitive and physical performance, and to characterize their interactions with pain-related brain networks (subproject 3, performed by PhD students co-supervised by the PI and his collaborators experienced with brain activations and networks measurement and analysis). The research costs include each year one full i) BSc Honours research fellowship, ii) MSc fellowship and iii) PhD fellowship. The methodological complexity is in line with the HPQs involved in each subproject. Subproject 1 focuses on behavioural studies. Subproject 2 requires the HPQ to master transcranial magnetic stimulation, and subproject 3 requires the HPQ to master brain imaging. For these reasons, these two subprojects will be the pillar of funding for PhD and MSc research fellowships. The multidisciplinary approach proposed is unique as it investigates the construct of effort and its perception across domains (mental and physical). The proposed work will contribute to the basic neuroscience of perception of effort by providing new insights into this perception involved i) in the self-regulation of behaviour in the context of goal-oriented tasks and ii) in the decreased performance in the presence of fatigue. As no study previously investigated the possibility that the negative impact of pain on performance could be mediated by its impact on perception of effort, this project contributes to better understand how facing pain makes voluntary tasks harder. The proposed work has a strong potential to open new lines of research to better understand how pain impacts performance.

每天，当我们执行自愿的身体和心理任务（例如爬楼梯或解决复杂的难题）时，我们就会感到努力。努力的看法与自愿行动有关，有助于代理意识，并提供有关个人行动成本的关键信息。有趣的是，虽然很明显，当我们感知痛苦时，日常生活的任务变得更加努力（或更艰难），但尚未研究这个假设。拟议的工作使用多学科的方法来了解疼痛如何影响表现和认知，身体和双重任务期间的努力感知。第一个目标是检验以下假设：在疼痛的存在下保存认知和身体性能是由于资源分配的增加所致，这反映在增加的感知努力中（Subproject 1，由本科生在本科生中由主要研究者监督的本科生-PI -PI -PI -PI -PI -PER由一名PhD学生进行指导）。第二个目标是检验以下假设：在认知和身体表现期间疼痛的情况下，对努力的感知增加与皮质脊髓兴奋性的改变有关（由PI监督的MSC学生执行）。第三个目标是确定参与努力感知，认知和身体表现期间涉及的大脑网络，并表征他们与疼痛相关的大脑网络的相互作用（Subproject 3，由PHD学生及其由PI和他的合作者共同监督大脑激活和网络测量和分析的PHD学生进行的。研究成本包括每年一年i）BSC荣誉研究奖学金，ii）MSC奖学金和III）博士学位奖学金。方法上的复杂性与每个子标本所涉及的HPQ一致。第1个副本着重于行为研究。 subproject 2要求HPQ掌握经颅磁刺激，而Subproject 3要求HPQ掌握脑成像。由于这些原因，这两个副本将是博士和MSC研究奖学金资金的支柱。 提出的多学科方法是独一无二的，因为它研究了努力及其在跨领域（心理和身体）的构建。拟议的工作将通过对涉及的这种感知提供新的见解，从而有助于努力的基本神经科学，i）在以目标为导向的任务的背景下对行为进行自我调节，而ii）在疲劳的情况下表现下降。由于没有研究以前研究了疼痛对绩效的负面影响可能是由于其对努力感知的影响所介导的，因此该项目有助于更好地了解面对疼痛如何使自愿任务变得更加困难。拟议的工作具有开放新的研究线的强大潜力，以更好地了解疼痛如何影响性能。