New electrode materials for arthroscopic probes

用于关节镜探头的新型电极材料

• 批准号: 568608-2021
• 负责人: Cicoira, Fabio
• 金额: $ 2.19万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=722509
• 关键词: New; electrode; materials; arthroscopic; probes; New; electrode; materials; arthroscopic; probes

This Alliance project is a collaboration between the group of Prof. Fabio Cicoira (Polytechnique Montréal) and Biomomentum Inc., a Canadian company based in Laval (QC), which produces and commercializes arthroscopic probes and mechanical testers. Biomomentum Inc. is developing a new arthroscopic probe, to be used for the precise and non-destructive assessment of articular cartilage. The current device uses an array of 37 Au electrodes on a spherical indenter to assess the electrical potentials generated during the compression of knee cartilage. The spherical shape of the probe and the lack of selectivity of the currently used fabrication technique leads to some performance limitations. To ensure reliable measurements of the electrical potential of each microelectrode, a complex electronic circuit with high input impedance is used. The electrical stability of such circuit requires additional electrical shielding and a well-controlled microelectrode impedance spectrum. Decreasing the interfacial impedance of microelectrodes is expected to improve electrical stability, provide better protection against environmental disturbances seen during arthroscopy and increase the signal-to-noise ratio in the quantitative assessment of cartilage properties.In this project, we will explore an innovative technology, based on electrochemical deposition of Au or a conductive polymer, to improve the performance of the arthroscopic probe. Such coatings, applied to each micro electrode, are expected to lead to lower and more reproducible impedance values. The impedance of the electrodes will be assessed first in physiological solution and successively in artificial cartilage. This project is expected to be very beneficial to Canadians. A reliable instrument capable of identifying early changes in cartilage will be a valuable tool for evaluating the effectiveness of disease modifying agents for osteoarthritis, in addition to guiding early interventions to prevent joint replacement, leading to significant reduction in costs for the Canadian healthcare system.

这个联盟项目是Fabio Cicoira教授（PolytechniqueMontréal）和Biomentum Inc.之间的合作，这是一家位于Laval（QC）的加拿大公司，该公司生产并商业化了关节镜问题和机械测试者。 Biomentum Inc.正在开发一种新的关节镜探针，用于对关节软骨的精确和无损评估。当前的设备在球形缩进器上使用37个Au电极的阵列来评估膝盖软骨压缩过程中产生的电势。探针的球形形状以及当前使用的制造技术缺乏选择性导致了一些性能限制。为了确保对每个微电极的电势的可靠测量，使用具有高输入阻抗的复杂电子电路。这种电路的电稳定性需要额外的电屏蔽和良好控制的微电极阻抗光谱。预计微电铸于关节镜检查中看到的环境灾害的降低有望提高电稳定性，并在软骨特性的定量评估中提高信噪比，并增加信噪比。这种应用于每个微电极的涂层预计将导致较低和更可再现的阻抗值。电极的阻抗将首先在物理溶液中评估并在人造软骨中成功。预计该项目对加拿大人非常有益。能够确定软骨早期变化的可靠仪器将是评估疾病修饰药对骨关节炎的有效性的宝贵工具，此外还指导早期干预措施防止关节置换，从而大大降低了加拿大医疗保健系统的成本。