A Microwave System for Medicinal Chemistry and Radiochemistry Research

用于药物化学和放射化学研究的微波系统

• 批准号: RTI-2021-00696
• 负责人: Hou, Jinqiang
• 金额: $ 2.87万
• 依托单位: Lakehead University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=718869
• 关键词: Microwave; System; Medicinal; Chemistry; Radiochemistry

The research programs of Drs. Hou, Campbell and Jiang have been searching for novel diagnostic and therapeutic tools by bringing together organic synthesis, radiochemistry, medicinal chemistry, computational chemistry and biochemistry. Successful discovery of novel therapeutic tools and diagnostic tools will significantly improve prevention, early diagnosis and management of diseases. The quality of life of many people will be improved if diseases are detected earlier, treated sooner, and monitored more effectively. It will lead to improved quality of health care and a reduced burden on the health care system. Dr. Hou's research focuses on the discovery of Fluorine-18 labelled molecular imaging agents for potential use in the imaging of cancer using Positron Emission Tomography (PET), and the development of radio-fluorination methods. Dr. Campbell's research group is focused on the development of new synthetic procedures for radiochemistry and applying them to the development of new imaging agents. Dr. Jiang's research involves the synthesis of compounds derived from peptides and carbohydrates for targeted cancer therapy. The microwave reactor system requested in this application is a versatile synthesizer that can perform rapid microwave assisted organic synthesis, and is a standard piece of equipment used throughout academic chemistry research labs and in the pharmaceutical industries. It offers several advantages including improved yield, shorter reaction times from days or hours down to minutes, and facilitates access to new chemical space as compared to conventional reflux heating using oil baths and hot plates. It has become an essential tool in synthetic organic chemistry, medicinal chemistry and radiochemistry and a key element in the research programs of Drs. Hou, Campbell and Jiang in the development of therapeutic and diagnostic molecular tools. The research programs supported by the requested equipment will benefit Canada in many ways. Firstly, the research would lead to the discovery of imaging probes for prevention, early diagnosis and management of diseases. Secondly, the invention of novel methods for radio-transformations and imaging tracers will enhance the competitivity of Canadian (radio)pharmaceutical industry. Lastly, the students who are involved in the proposed research programs will receive in-depth training on the most advanced microwave-assisted synthesis and will gain comprehensive knowledge and hands-on skills for drug/imaging agent synthesis and discovery. The equipment, along with the research programs, will allow for the training of next generation scientists to better prepare for a successful career in academia or pharmaceutical industry.

博士的研究计划。 Hou，Campbell和Jiang一直通过将有机合成，放射化学，药物化学，计算化学和生物化学汇总在一起，一直在寻找新颖的诊断和治疗工具。成功发现新型治疗工具和诊断工具将显着改善预防，早期诊断和疾病管理。如果较早发现疾病，早点治疗并更有效地监测疾病，许多人的生活质量将得到改善。这将导致改善医疗保健质量，并减轻医疗保健系统的负担。 Hou博士的研究重点是发现氟-18标记的分子成像剂，用于使用正电子发射断层扫描（PET）和射氟化方法的开发在癌症中的潜在使用。坎贝尔博士的研究小组致力于开发放射化学的新合成程序，并将其应用于新成像剂的开发。 Jiang博士的研究涉及源自靶向癌症治疗的肽和碳水化合物的化合物的合成。本应用中要求的微波反应堆系统是一种多功能合成器，可以执行快速的微波辅助有机合成，并且是整个学术化学研究实验室和制药行业中使用的标准设备。它提供了几种优势，包括提高的收益率，几天或几小时到几分钟到几分钟的反应时间较短，并促进与使用油浴和热板的常规回流加热相比，可以进入新的化学空间。它已成为合成有机化学，药物化学和放射化学以及DRS研究计划中的关键要素的重要工具。 Hou，Campbell和Jiang在开发治疗和诊断分子工具方面。所请求的设备支持的研究计划将在许多方面使加拿大受益。首先，这项研究将导致发现预防，早期诊断和疾病治疗的成像探针。其次，用于放射性转化和成像示踪剂的新方法的发明将增强加拿大（无线电）制药行业的竞争力。最后，参与拟议的研究计划的学生将接受有关最先进的微波辅助合成的深入培训，并将获得药物/成像剂合成和发现的全面知识和动手技能。该设备以及研究计划将允许对下一代科学家进行培训，以更好地为在学术界或制药行业的成功事业做好准备。