A Microwave System for Medicinal Chemistry and Radiochemistry Research

用于药物化学和放射化学研究的微波系统

• 批准号: RTI-2021-00696
• 负责人: Hou, Jinqiang
• 金额: $ 2.87万
• 依托单位: Lakehead University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=718869
• 关键词: Microwave; System; Medicinal; Chemistry; Radiochemistry

The research programs of Drs. Hou, Campbell and Jiang have been searching for novel diagnostic and therapeutic tools by bringing together organic synthesis, radiochemistry, medicinal chemistry, computational chemistry and biochemistry. Successful discovery of novel therapeutic tools and diagnostic tools will significantly improve prevention, early diagnosis and management of diseases. The quality of life of many people will be improved if diseases are detected earlier, treated sooner, and monitored more effectively. It will lead to improved quality of health care and a reduced burden on the health care system. Dr. Hou's research focuses on the discovery of Fluorine-18 labelled molecular imaging agents for potential use in the imaging of cancer using Positron Emission Tomography (PET), and the development of radio-fluorination methods. Dr. Campbell's research group is focused on the development of new synthetic procedures for radiochemistry and applying them to the development of new imaging agents. Dr. Jiang's research involves the synthesis of compounds derived from peptides and carbohydrates for targeted cancer therapy. The microwave reactor system requested in this application is a versatile synthesizer that can perform rapid microwave assisted organic synthesis, and is a standard piece of equipment used throughout academic chemistry research labs and in the pharmaceutical industries. It offers several advantages including improved yield, shorter reaction times from days or hours down to minutes, and facilitates access to new chemical space as compared to conventional reflux heating using oil baths and hot plates. It has become an essential tool in synthetic organic chemistry, medicinal chemistry and radiochemistry and a key element in the research programs of Drs. Hou, Campbell and Jiang in the development of therapeutic and diagnostic molecular tools. The research programs supported by the requested equipment will benefit Canada in many ways. Firstly, the research would lead to the discovery of imaging probes for prevention, early diagnosis and management of diseases. Secondly, the invention of novel methods for radio-transformations and imaging tracers will enhance the competitivity of Canadian (radio)pharmaceutical industry. Lastly, the students who are involved in the proposed research programs will receive in-depth training on the most advanced microwave-assisted synthesis and will gain comprehensive knowledge and hands-on skills for drug/imaging agent synthesis and discovery. The equipment, along with the research programs, will allow for the training of next generation scientists to better prepare for a successful career in academia or pharmaceutical industry.

博士的研究计划。侯、坎贝尔和江一直在将有机合成、放射化学、药物化学、计算化学和生物化学结合起来寻找新的诊断和治疗工具。成功发现新型治疗工具和诊断工具将显着改善疾病的预防、早期诊断和管理。如果疾病能更早发​​现、更早治疗和更有效监测，许多人的生活质量将会得到改善。它将提高医疗保健质量并减轻医疗保健系统的负担。侯博士的研究重点是发现氟 18 标记的分子成像剂，其可用于使用正电子发射断层扫描 (PET) 进行癌症成像，以及开发放射性氟化方法。 Campbell 博士的研究小组专注于放射化学新合成程序的开发，并将其应用于新显像剂的开发。江博士的研究涉及从肽和碳水化合物衍生的化合物的合成，用于靶向癌症治疗。本应用中要求的微波反应器系统是一种多功能合成器，可以进行快速微波辅助有机合成，并且是整个学术化学研究实验室和制药行业使用的标准设备。与使用油浴和热板的传统回流加热相比，它具有多种优点，包括提高产率、将反应时间从几天或几小时缩短到几分钟，并有助于进入新的化学空间。它已成为合成有机化学、药物化学和放射化学的重要工具，也是博士研究项目的关键要素。 Hou、Campbell 和 Jiang 致力于开发治​​疗和诊断分子工具。所需设备支持的研究计划将使加拿大在许多方面受益。首先，该研究将导致用于疾病预防、早期诊断和管理的成像探针的发现。其次，无线电变换和成像示踪剂新方法的发明将增强加拿大（无线电）制药业的竞争力。最后，参与拟议研究项目的学生将接受最先进的微波辅助合成的深入培训，并将获得药物/显像剂合成和发现的全面知识和实践技能。这些设备和研究项目将有助于培训下一代科学家，以便更好地为学术界或制药行业的成功职业生涯做好准备。