Interplay between mechanical behaviour of the spine and skeletal muscle

脊柱和骨骼肌机械行为之间的相互作用

• 批准号: RGPIN-2020-04521
• 负责人: Brown, Stephen
• 金额: $ 3.42万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=716645
• 关键词: Interplay; between; mechanical; behaviour; spine

The primary long-term goal of this research program is to advance the understanding of the biomechanical relationship between spine and muscle function. Spine muscles demonstrate a unique design, function differently from many other muscles of the body, and have an important role in maintaining the stability of the spine. Specifically, the spine is a highly unstable structure that cannot function in the absence of a strong and coordinated set of muscles. There are a number of naturally occurring states that place high demand on these muscles which, in turn, can necessitate adaptation and subsequently alter their ability to stabilize the spine. Similarly, a change in the stability level of the spine can stimulate adaptation in the surrounding muscles. Spine stability can therefore be viewed as a natural mechanical and physiological interaction between passive and active tissues, which defines the demands on, and structure of, the spine. The short-term focus of this grant is designed to answer questions relating to how the spine and its muscles adapt their functional capabilities to ensure the maintenance of a stable spine. Basic scientific studies will be conducted, in a rat model, to progressively alter (decrease or increase) the level of stability in the spine or the stabilization ability of the muscles. Measurements will be taken of structural and active contractile changes in the muscles at the cellular-level, which determine their force and movement-generating abilities, as well as changes to the mechanical properties of the spine itself. These animal-based studies will be partnered with studies of human volunteers, which will use measurements of muscle electrical activity and spine movement to gain insight into how muscles respond and compensate for alterations in spine stiffness and mobility, and whether this differs between males and females. This will provide novel and impactful information regarding mechanisms that drive muscle and spine adaptation, behaviour and usage patterns. Ultimately this knowledge can contribute to the development of novel strategies to prevent and rehabilitate low back disorders and pain in the Canadian population.

该研究计划的主要长期目标是增进对脊柱和肌肉功能之间生物力学关系的理解。脊柱肌肉表现出独特的设计，其功能不同于身体的许多其他肌肉，并且在维持脊柱的稳定性方面具有重要作用。具体来说，脊柱是一个高度不稳定的结构，如果没有一组强大而协调的肌肉就无法发挥作用。许多自然发生的状态对这些肌肉提出了很高的要求，这反过来又需要适应并随后改变它们稳定脊柱的能力。同样，脊柱稳定性水平的变化可以刺激周围肌肉的适应。因此，脊柱稳定性可以被视为被动组织和主动组织之间的自然机械和生理相互作用，它定义了对脊柱的要求和结构。这笔赠款的短期重点旨在回答有关脊柱及其肌肉如何调整其功能能力以确保维持脊柱稳定的问题。将在大鼠模型中进行基础科学研究，以逐步改变（减少或增加）脊柱的稳定性水平或肌肉的稳定能力。将在细胞水平上测量肌肉的结构和主动收缩变化，这决定了它们的力量和运动产生能力，以及脊柱本身机械特性的变化。这些基于动物的研究将与人类志愿者的研究合作，利用肌肉电活动和脊柱运动的测量来深入了解肌肉如何反应并补偿脊柱硬度和活动性的变化，以及男性和女性之间是否存在差异。这将提供有关驱动肌肉和脊柱适应、行为和使用模式的机制的新颖且有影响力的信息。最终，这些知识可以有助于制定新策略来预防和康复加拿大人口的腰部疾病和疼痛。