Tracing element pathways and processes of Ca, Fe, Cu, and Zn in the geosphere and biosphere: Precision measurement with isotopic tools

追踪地质圈和生物圈中 Ca、Fe、Cu 和 Zn 的元素路径和过程：使用同位素工具进行精确测量

• 批准号: RGPIN-2020-04212
• 负责人: Wieser, Michael
• 金额: $ 2.48万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=714955
• 关键词: Tracing; element; pathways; processes; Ca

The focus of my Research Group is the development of high precision metal isotope abundance measurement techniques and their application to interpreting these data in the context of metal processes and pathways of metals in living systems. We see short term impacts in advancing our understanding of how metals interact through biochemical processes. As successfully demonstrated in a recent collaborative experiment with colleagues in Medicine exploring changes in copper assimilation affected by antibiotic treatment (Miller et al., 2019), isotopic tools have the potential to reveal biochemical pathways that are hidden from more traditional analytical approaches. In the long term, we believe our research is transformative and our vision is that isotope abundance tools become a standard and vital component in maintaining health and wellness. This research program is the critical fundamental step in this direction. In the near term, the goals of the program are to develop and deploy stable isotope techniques to uncover the distribution and variability of isotopic abundances of Ca, Fe, Cu, and Zn in biogeochemical systems. We seek to identify critical interactions where changes in isotopic composition occur and to understand the physiochemical processes responsible for isotopic variability. The objectives of this project are realized through development of meteorologically sound analytical techniques to measure isotopic composition such that one extracts reliable information. Results are placed within a theoretical context based on computational models to derive a meaningful interpretation of the results. The fundamental nature and the interdisciplinary audience of the research program are reflected in the journals where we publish as well as the journals cited in the References attached to this DG application. The past five years saw significant progress and the proposed research is a continuation of this successful research program. Highlights include attracting a diverse group of capable HQP to the research group (my first PhD students graduate, first postdoctoral scholar joined the group, international PhD students visiting the lab). We published our work in leading journals such as Proceedings of the National Academy of Sciences, Metallomics, and the Journal of Analytical Atomic Spectrometry. We embarked on productive collaborations with colleagues in Health Sciences (K. Sharkey, Cumming School of Medicine, UofC), Bioscience (V. Zaremberg and H. Vogel, UofC), Marine Biogeochemistry (A. Bowie and B. Proemse, University of Tasmania, Australia) and Chemistry (J. Gailer, UofC; T. Prohaska and J. Irrgeher, Montanuniversität, Leoben, Austria). Finally, we have attracted new sources of funding from diverse sources.

我的研究小组的重点是开发高精度金属同位素抽象测量技术及其在生命系统中金属的金属过程和金属途径中解释这些数据的应用。我们看到短期影响在促进我们对金属如何通过生化过程相互作用的理解方面的影响。正如在最近与医学同事的最新合作实验中成功证明的那样，探索受抗生素治疗影响的铜同化的变化（Miller等，2019），同位素工具具有揭示生化途径的潜力，这些途径被更传统的分析方法隐藏了。从长远来看，我们认为我们的研究具有变革性，我们的愿景是同位素抽象工具成为维持健康和健康的标准和重要组成部分。该研究计划是朝这个方向迈出的关键基本步骤。 在短期内，该程序的目标是开发和部署稳定的同位素技术，以揭示生物地球化学系统中Ca，Fe，Fe，Cu和Zn的同位素丰度的分布和变异性。我们试图确定同位素组合物发生变化并了解负责同位素变异性的物理过程的关键相互作用。该项目的目标是通过开发气象学上声音分析技术来测量同位素组成的，从而实现了该项目的目标，从而提取了可靠的信息。结果放在基于计算模型的理论上下文中，以得出对结果的有意义的解释。研究计划的基本性质和跨学科受众反映在我们发布的期刊以及此DG应用程序所述的参考文献中所引用的期刊。 在过去的五年中，取得了重大进展，拟议的研究是该成功研究计划的延续。亮点包括吸引一个有能力的HQP的潜水员参加研究小组（我的第一届博士生毕业生，第一学博士学位学校加入了该小组，国际博士学位学生参观了实验室）。我们在领先的期刊上发表了工作，例如国家科学院，金属学院和分析原子光谱学杂志。我们开始与健康科学同事（K. Sharkey，Cumming of Medicine，UOFC），Bioscience（V. Zaremberg和H. Vogel，UOFC），Marine Biogeochemention，A. Bowie和B. Proemse（澳大利亚塔斯马尼亚大学，澳大利亚塔斯马尼亚大学）和化学（J. Gailer，Uofc;奥地利莱本）的Montanuniversität）。最后，我们吸引了潜水员来源的新资金来源。