Multifunctional Hybrid Nanomaterials: Development to Biomedical Applications

多功能杂化纳米材料：生物医学应用的发展

• 批准号: RGPIN-2018-05799
• 负责人: Nazemi, Ali
• 金额: $ 2.11万
• 依托单位: Université du Québec à Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=713380
• 关键词: Multifunctional; Hybrid; Nanomaterials; Development; Biomedical

Under the general theme of polymer and dendrimer chemistry, the objective of this research program, consisting of three projects, is to create new classes of macromolecules that converge in their use in nanomedicine. Research in fundamental science is the basis for development of materials for real world applications. Through this research program, our short-term goal is to rationally design new structures and study their unique resulting properties, and, in the long-term, use them as building blocks to fabricate novel nanomaterials for biomedical applications. The first project aims to create a new class of well-defined metallopolymers. Although a wide variety of metallopolymers have been reported, those based on N-heterocyclic crabenes (NHCs) are very rare. This is in sharp contrast with the fact that NHCs have been shown to form strong bonds to many metal ions. In our approach, we will synthesize a variety of metallopolymers based on NHCmetal complexes with metals such as Au and Ag. We will then use these new materials as novel precursors for the synthesis of nanoparticles with controlled dimensions and compositions and, hence, fine-tuned optoelectronic properties for dry delivery applications. In the second project, we will introduce crystalline linear-dendritic block copolymers (BCPs) as new self-assembling building blocks for nanomaterial engineering. Although the synthesis and self-assembly of amorphous linear-dendritic BCPs is reported to some extent, there are no examples of linear-dendritic BCPs with crystalline segments. Using this newly-developed class of BCPs, we will form nanomaterials that have long blood circulation times while, at the same time, are capable of effectively interacting with biological systems. The focus of the third project will be the design and synthesis of nanomaterials based on highly-fluorinated dendrimers. Unlike fluorinated linear polymers, there are only handful reports showcasing fluorinated dendrimers in the literature. Using our new fluorinated dendrimers, their in-depth self-assembly study can open exciting opportunities in nanomedicine. Besides their use as drug delivery vehicles, we will also investigate these materials as inherently-active nanostrutures in 19F magnetic resonance imaging. The proposed research program is at the cutting edge of functional polymer-, dendrimer-, and nanomaterials fields. Outcomes of this innovative program will make high-impact contributions to the highly-growing field of materials chemistry, nationally and internationally. Through this program, highly qualified personnel will receive extensive training in organic, inorganic, and materials synthesis and characterization techniques, and will be exposed to extensive collaboration opportunities with bio- and computational chemists, all of which will be essential to develop necessary skillset for their future careers.

在聚合物和树枝状聚合物化学的一般主题下，该研究计划的目的由三个项目组成，是创建新的大分子类，以融合其在纳米医学中的使用。基础科学的研究是开发现实世界应用材料的基础。通过该研究计划，我们的短期目标是合理设计新的结构并研究其独特的属性，从长远来看，将它们用作为生物医学应用制造新型纳米材料的基础。 第一个项目旨在创建新的定义明确的金属聚合物类。尽管已经报道了各种各样的金属聚合物，但基于N-杂环蟹素（NHC）的金属聚合物非常罕见。这与已证明NHC与许多金属离子形成牢固的键相反。在我们的方法中，我们将基于NHCMetal复合物与金属（例如Au和Ag）合成各种金属聚合物。然后，我们将使用这些新材料作为具有控制尺寸和组成的纳米颗粒的新型前体，因此，用于干燥递送应用的微调光电特性。 在第二个项目中，我们将引入晶体线性树枝状块共聚物（BCP），作为纳米材料工程的新的自组装构建块。尽管在某种程度上报告了无定形线性树枝状BCP的合成和自组装，但没有线性树枝状BCP具有晶体段的线性树枝状BCP。使用这种新开发的BCP类别，我们将形成纳米材料的血液循环时间很长，同时也能够有效与生物系统相互作用。 第三个项目的重点是基于高氟化树状聚合物的纳米材料的设计和合成。与氟化的线性聚合物不同，只有少数报道在文献中展示了氟化的树枝状聚合物。使用我们新的氟化树状聚合物，其深入的自组装研究可以在纳米医学中打开激动人心的机会。除了用作药物输送车辆外，我们还将在19F磁共振成像中研究这些材料作为固有活性的纳米压。 拟议的研究计划处于功能性聚合物，树突聚合物和纳米材料领域的最前沿。这项创新计划的成果将在国内和国际上为材料化学的高度增长领域做出高影响力的贡献。通过该计划，高素质的人员将接受广泛的有机，无机和材料综合和特征技术的培训，并将与生物和计算化学家接触到广泛的合作机会，所有这些对于为其发展提供必要的技能至关重要。未来的职业。