Assessment, monitoring, and stratification of disease progression for Type II Diabetes Mellitus

II 型糖尿病疾病进展的评估、监测和分层

• 批准号: RGPIN-2016-04120
• 负责人: Kwok, Ezra
• 金额: $ 2.4万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=708994
• 关键词: Assessment; monitoring; stratification; disease; progression

Most of the long-term health problems associated with diabetes, such as nephropathy, retinopathy, neuropathy, cardiovascular diseases and cerebral vascular events, result from the sustained hyperglycemia (blood glucose > 11 mmol/L). Statistics Canada data shows that in 2005, 4.3% of adults was diagnosed with diabetes mellitus. This increased to 6.8% in 2008/09. According to the Public Health Agency, there are an estimated 60,000 new cases of diagnosed diabetes every year in Canada. Frequent glucose monitoring and tight glucose control have been shown to improved patient health, better quality of life, and tremendous healthcare savings. My research has taken two directions towards a common goal. The first direction of my research is specifically targeted towards the development of a physiological model suitable for simulation, performance assessment, and evaluation of diabetic managements for clinical purposes. The second direction is related to the measurement of blood glucose. Any frequent glucose monitoring requires the use of a reliable non-invasive glucose sensor. Different approaches have been used to develop such a sensor which is considered the "holy grail" in diabetic monitoring and control. Most common approaches include light-based and enzyme-based measurements of body fluids such as sweat and blood. My on-going work has been focusing on the light-based approach. We also developed the first multi-organ compartment diabetic model for type II diabetes mellitus and pioneered the first device to demonstrate the proof of concept to measure accurately glucose level in solution and serum. The long-term objectives of my research are 1) to improve the management of blood glucose by employing a clinically-relevant physiological model and fault detection features suitable for monitoring and control, and 2) to improve the accuracy of optical glucose sensors. For the next five years, four specific projects have been identified to guide this research program into reaching its long-term objectives: 1) Develop a fault detection and isolation scheme for the insulin-glucose system using advanced statistical methods. 2) Evaluate the pharmacological impact of different treatment approaches. 3) Develop multi-laser-based micro-sensor based on absorption/reflectance spectroscopy 4) Development of evanescent field sensors for glucose measurements. The ultimate goal of my research is to benefit our society by advancing engineering research into bioprocesses particularly in managing diabetes mellitus, which is one of the most prevalent diseases affecting Canadians today.

大多数与糖尿病相关的长期健康问题，如肾病、视网膜病、神经病、心血管疾病和脑血管事件，都是由持续高血糖（血糖> 11 mmol/L）引起的。加拿大统计局的数据显示，2005年，4.3%的成年人被诊断患有糖尿病。 2008/09 年这一数字增至 6.8%。据公共卫生局称，加拿大每年估计有 60,000 例新诊断糖尿病病例。事实证明，频繁的血糖监测和严格的血糖控制可以改善患者的健康、提高生活质量并节省大量医疗费用。我的研究朝着一个共同的目标迈出了两个方向。我研究的第一个方向专门针对开发适合临床目的的糖尿病管理模拟、性能评估和评估的生理模型。第二个方向与血糖的测量有关。任何频繁的血糖监测都需要使用可靠的无创血糖传感器。人们使用了不同的方法来开发这种传感器，该传感器被认为是糖尿病监测和控制中的“圣杯”。最常见的方法包括对汗液和血液等体液进行基于光和酶的测量。我正在进行的工作一直专注于基于光的方法。我们还开发了第一个用于 II 型糖尿病的多器官室糖尿病模型，并率先开发了第一个设备来演示精确测量溶液和血清中葡萄糖水平的概念验证。我研究的长期目标是 1) 通过采用临床相关的生理模型和适合监测和控制的故障检测功能来改善血糖管理，2) 提高光学葡萄糖传感器的准确性。在接下来的五年里，已经确定了四个具体项目来指导该研究计划实现其长期目标： 1) 使用先进的统计方法开发胰岛素-葡萄糖系统的故障检测和隔离方案。 2) 评估不同治疗方法的药理学影响。 3）开发基于吸收/反射光谱的多激光微传感器 4) 开发用于葡萄糖测量的倏逝场传感器。 我研究的最终目标是通过推进生物过程的工程研究，特别是在糖尿病管理方面造福我们的社会，糖尿病是当今影响加拿大人的最普遍的疾病之一。