Design and implementation of an ultra-small vital-signs-monitoring multi-sensing microsystem for COVID-19 management

用于 COVID-19 管理的超小型生命体征监测多传感微系统的设计和实现

• 批准号: 560393-2020
• 负责人: Gosselin, Benoit
• 金额: $ 6.56万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=706596
• 关键词: Design; implementation; ultra; small; vital

This collaborative research project, which counts on a multidisciplinary team, including two universities, two Canada research Chairs, and three innovative partner organizations in medical technologies and advanced manufacturing, aims to design, manufacture and test a tiny, inexpensive and easy-to-use wearable multi-sensing device to continuously monitor patients remotely, and help greatly to manage COVID-19. This device will be useful both for the follow-up of patients that tested positive as for the monitoring of patients at risk such as the elderly or immunocompromised. We envision the smallest vital signs monitoring device ever designed. This microsensor will achieve an extreme level of miniaturization by combining CMOS custom integrated circuits with ultra-small electronic components available off the shelf (COTS) through an advanced 3D-IC integration strategy that will be developed in collaboration with CMC Microsystems. The miniature multi-sensing device will address the requirements of iMD research, which strives to provide patients with inexpensive multi-sensing monitoring devices of extended battery life to continuously measure temperature, heart rate (HR), blood pressure (BP), oxygen saturation (SPO2) and respiratory rate (RR) remotely. Application-specific integrated circuits (ASICs) and ultra-small COTS will be combined and interconnected together using the advanced system-in-package chip integration that will be developed based on silicon interposers. The power consumption of the whole microsensor will be very low, within a few hundreds of microwatts, in order to extend the battery life. A custom software application will be developed in collaboration with Nexless to accurately and continuously read patients' vital signs and close the loop between the patients and various connected devices, such as Nexless's ventilators. At scale, our device will be inexpensive and provide direct and effective relief to patients, their families, and health care workers. Furthermore, the ability of Canada to reopen its economy will depend on our ability to measure and monitor the fluctuation in COVID-19 cases. Our device could be of immense help in that effort.

该合作研究项目依靠多学科团队，包括两所大学、两名加拿大研究主席以及医疗技术和先进制造领域的三个创新合作伙伴组织，旨在设计、制造和测试一种微型、廉价且易于使用的产品可穿戴多传感设备可远程持续监控患者，并极大地帮助管理 COVID-19。该设备既可用于跟踪检测呈阳性的患者，也可用于监测高危患者（例如老年人或免疫功能低下的患者）。我们设想有史以来设计的最小的生命体征监测设备。该微传感器将通过与 CMC Microsystems 合作开发的先进 3D-IC 集成策略，将 CMOS 定制集成电路与现成的超小型电子元件 (COTS) 相结合，从而实现极致的小型化。该微型多传感设备将满足 iMD 研究的要求，该研究致力于为患者提供价格低廉且电池寿命更长的多传感监测设备，以连续测量温度、心率 (HR)、血压 (BP)、血氧饱和度 ( SPO2) 和远程呼吸频率 (RR)。专用集成电路 (ASIC) 和超小型 COTS 将使用基于硅中介层开发的先进系统级封装芯片集成进行组合和互连。整个微传感器的功耗会非常低，在几百微瓦以内，以延长电池寿命。将与 Nexless 合作开发定制软件应用程序，以准确、连续地读取患者的生命体征，并关闭患者与各种连接设备（例如 Nexless 的呼吸机）之间的循环。从规模上看，我们的设备将价格低廉，并为患者、其家人和医护人员提供直接有效的缓解。此外，加拿大重新开放经济的能力将取决于我们衡量和监测 COVID-19 病例波动的能力。我们的设备可以在这方面提供巨大的帮助。