Paper-based and capillary-driven microfluidics platforms for allergy tests

用于过敏测试的纸基和毛细管驱动的微流体平台

• 批准号: 516525-2017
• 负责人: MacDonald, Brendan
• 金额: $ 2.41万
• 依托单位: University of Ontario Institute of Technology
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695289
• 关键词: Paper; based; capillary; driven; microfluidics; Paper; based; capillary; driven; microfluidics

Allergies are a pervasive problem that affects more than 60 million North Americans. The standard test is the skin prick method, where a doctor places various allergens on the skin and pricks the skin with a needle to induce an allergic reaction. The reaction can be severely irritating with both swelling and itching. Many patients (especially children) find the skin prick test invasive and uncomfortable, and some are not suitable candidates. The proposed research will contribute to the development of a safe, simple and certain skin patch that ensures patients are diagnosed as quickly and comfortably as possible, which will increase testing and keep patients informed of their allergic conditions.The objective of the proposed research is to utilize capillary-driven microfluidic strategies, such as flow through paper and thread-based devices and electrochemistry, to develop a skin patch that can be commercialized by our industrial partner, ExVivo Labs Inc. The strategies will help to isolate and concentrate the chemicals found in patient samples to enable detection of allergic conditions even in small volumes of sample fluid. The patient samples will be interstitial fluid, which can be collected painlessly through a small patch of microneedles applied to the skin. The sample will be wicked into the microfluidic device we develop and a visual signal will be generated to indicate if the patient is allergic to the allergens being tested or not.The research will be undertaken in collaboration with a Canadian industry partner, ExVivo Labs, who will gain access to the knowledge, expertise, and resources necessary to overcome the challenges associated with developing their allergy test skin patch, and as a result to develop a successful commercial product. The research outcomes from the proposed CRD Grant would enable additional expansion providing more jobs and increasing the likelihood for expanding the Canadian economy with user-friendly diagnostic test products.

过敏是一个普遍的问题，影响了超过6000万北美人。标准测试是皮肤刺法，医生将各种过敏原放置在皮肤上，并用针刺的皮肤刺穿皮肤以诱导过敏反应。反应可能会因肿胀和瘙痒而严重刺激。许多患者（尤其是儿童）发现皮肤刺测试的侵入性和不舒服，有些是不合适的候选者。拟议的研究将有助于开发安全，简单和某些皮肤贴剂，以确保患者尽可能快速，舒适地诊断，这将增加测试并使患者了解其过敏状况。拟议的研究的目标是利用毛细管驱动的微流体驱动的微流体策略，例如通过纸张和螺纹的设备和型号的互动，可以通过纸张和型号进行培养，以便我们的既有互助，又可以使您的既有搭配互为互为插入式搭配。 Inc.这些策略将有助于分离并集中在患者样品中发现的化学物质，即使在少量样品流体中，也能够检测到过敏状况。患者样品将是间质性液体，可以通过涂在皮肤上的一小片微针中无痛地收集。 The sample will be wicked into the microfluidic device we develop and a visual signal will be generated to indicate if the patient is allergic to the allergens being tested or not.The research will be undertaken in collaboration with a Canadian industry partner, ExVivo Labs, who will gain access to the knowledge, expertise, and resources necessary to overcome the challenges associated with developing their allergy test skin patch, and as a result to develop a successful commercial product.拟议中的CRD赠款的研究结果将使更多的扩张提供更多的工作，并增加使用用户友好的诊断测试产品扩展加拿大经济的可能性。