Control of human standing posture

人体站立姿势的控制

• 批准号: 105424-2013
• 负责人: Garland, Jayne
• 金额: $ 2.4万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=684610
• 关键词: Control; human; standing; posture

My NSERC-funded research program examines how the brain controls muscle force and movement, particularly under conditions of fatigue and postural control, through the study of motor unit behaviour. The motor unit is the means for the commands from the brain to create forces in the muscle. Maintenance of upright standing is fundamental to human mobility. Standing balance is of utmost importance to prevent the devastating consequences of falls in the aged. The calf muscles are essential for standing balance and previously all the calf muscles were thought to be activated uniformly in standing. Traditionally, muscle activation is measured with two surface electrodes or fine-wire electrodes placed in the muscle but these techniques collect information from motor units confined to a relatively small muscle region (mm to cm). We will use an innovative way of studying populations of motor units occupying different regions of the calf muscles. This is achieved by using grids of 20-24 very small electrodes (called HDS-EMG) placed over the entire muscle. Using this novel technology, we will examine whether there are important regional differences in how the muscles must react to balance disturbances. We will create balance disturbances by applying loads at the subjects' hips. Loads of varying magnitude will be applied in different directions (with and without fatiguing the calf muscles) to determine if the calf muscles are activated in specific regions based on the characteristics of the balance disturbance. Young healthy subjects will be compared to elderly subjects to determine if the regional activation serves to fine tune the postural response to the balance disturbance which may be lacking in the elderly. Finally, we will explore the relationship of activation of areas of the brain with areas of localized activity in the muscle to determine if the brain influences the pattern of muscle activation during balance disturbances. This knowledge will advance our understanding of human postural control and provide insight on falls in the elderly.

我的 NSERC 资助的研究项目通过运动单位行为的研究，研究大脑如何控制肌肉力量和运动，特别是在疲劳和姿势控制的情况下。 运动单位是大脑发出命令在肌肉中产生力量的手段。 保持直立站立是人类活动的基础。 站立平衡对于防止老年人跌倒造成的破坏性后果至关重要。 小腿肌肉对于站立平衡至关重要，以前认为所有小腿肌肉在站立时都会被均匀激活。 传统上，肌肉激活是通过放置在肌肉中的两个表面电极或细线电极来测量的，但这些技术从局限于相对较小的肌肉区域（毫米到厘米）的运动单位收集信息。 我们将使用一种创新的方法来研究占据小腿肌肉不同区域的运动单位群体。 这是通过使用放置在整个肌肉上的 20-24 个非常小的电极（称为 HDS-EMG）网格来实现的。 利用这项新技术，我们将检查肌肉对平衡障碍的反应是否存在重要的区域差异。 我们将通过在受试者的臀部施加负载来造成平衡障碍。 将在不同方向施加不同大小的负载（有或没有使小腿肌肉疲劳），以根据平衡干扰的特征确定特定区域的小腿肌肉是否被激活。 将年轻健康受试者与老年受试者进行比较，以确定区域激活是否有助于微调老年人可能缺乏的对平衡障碍的姿势反应。 最后，我们将探讨大脑区域的激活与肌肉局部活动区域的关系，以确定大脑是否影响平衡障碍期间的肌肉激活模式。 这些知识将增进我们对人类姿势控制的理解，并为老年人跌倒提供见解。