Market Study of Compressed Ultrafast Transmission Electron Microscopy (CUTEM)

压缩超快透射电子显微镜 (CUTEM) 的市场研究

• 批准号: 544458-2019
• 负责人: Liang, Jinyang
• 金额: $ 0.88万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=674805
• 关键词: Market; Study; Compressed; Ultrafast; Transmission

Transmission electron microscopy (TEM) is indispensable for numerous applications, including materials science, car industry, industrial inspection, nanotechnology, life sciences, semiconductors, mining & minerals sectors, and oil & gas industry. As Grand View Research Inc. reported in October 2018, the global electron microscope market size was valued at USD 3.2 billion in 2017. It is anticipated to expand at a CAGR of 7.4% over the forecast period (2018-2025). However, most TEM machines have moderate imaging speeds up to 200 frames per second, which are ultimately limited by imaging sensors. To overcome this limitation, dynamic TEM (D-TEM) was invented, but it has various drawbacks in the sequence depth, the temporal resolution, and the field of view. Thus far, there is no existing single-shot movie-mode TEM that could record hundreds of frames with sub-nanosecond temporal resolution and nanometer spatial resolution. Recently, we invented compressed ultrafast transmission electron microscopy (CUTEM) that offers a quantum leap in imaging capability from state-of-the-art D-TEM. CUTEM combines laser-assisted TEM with computational imaging methodologies based on compressed sensing (CS). With a minimum modification of commercially available D-TEM systems, CUTEM will add two additional components. First, a transmissive mask with a binary random pattern will spatially encode the electron probe beam. Second, a linear ramp voltage will be applied to the pair(s) of sweep electrodes to temporally shear individual temporal frames. Besides innovation in hardware, the proposed method will leverage a CS-based algorithm to retrieve information in time and two-dimensional space. This invention will achieve simultaneously a picosecond temporal resolution and a nanometer spatial resolution. It will also be able to record more than 100 frames in a single acquisition. Thus, it will provide an attractive electron imaging product for capturing irreversible chemical reactions, non-repeatable structural phenomena, and difficult-to-reproduce radiation-matter interactions.

传输电子显微镜（TEM）对于多种应用是必不可少的，包括材料科学，汽车行业，工业检查，纳米技术，生命科学，半导体，矿业和矿产领域以及石油和天然气行业。正如Grand View Research Inc.在2018年10月报道的那样，全球电子显微镜市场规模在2017年的价值为32亿美元。预计在预测期（2018-2025）的复合年增长率为7.4％。但是，大多数TEM机器的成像速度高达每秒200帧，最终受到成像传感器的限制。为了克服这一限制，发明了动态TEM（D-TEM），但在序列深度，时间分辨率和视野中具有各种缺点。到目前为止，还没有现有的单发电影模式TEM可以记录数百个具有子纳秒时间分辨率和纳米空间分辨率的帧。 最近，我们发明了压缩的超快透射电子显微镜（CUCEM），该透射电子显微镜（CUCEM）从最新的D-TEM中提供了成像能力的量子飞跃。 CUCEM将激光辅助的TEM与基于压缩感应（CS）的计算成像方法结合在一起。通过对市售D-TEM系统的最小修改，Cucem将增加两个其他组件。首先，具有二进制随机图案的透射罩将在空间上编码电子探针梁。其次，将线性坡道电压应用于扫描电极的一对，以临时剪切单个时间帧。除了硬件的创新外，该建议的方法还将利用基于CS的算法在时间和二维空间中检索信息。本发明将同时实现比秒时间分辨率和纳米空间分辨率。它还可以在一次收购中记录100多个帧。因此，它将提供一种有吸引力的电子成像产品，用于捕获不可逆的化学反应，不可重复的结构现象以及难以促进的辐射 - 产物相互作用。