Wireless neurophotonic probes for the interrogation of neurons in memory circuits

用于询问记忆电路中神经元的无线神经光子探针

• 批准号: 508406-2017
• 负责人: Poon, Joyce
• 金额: $ 17.05万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=662448
• 关键词: Wireless; neurophotonic; probes; interrogation; neurons

As the average age of the population of Canada and the developed world rises,**neurodegenerative conditions will become increasingly prevalent and a growing burden on**the healthcare system and economy. A major neurodegenerative disease is Alzheimers**disease (AD), which causes memory and cognition loss. AD and dementia affect roughly 1.1**million Canadians and incur an economic cost of $10.4B per year in Canada. Currently, there**is no cure or effective treatment. The Lancet Neurology Commission recently stated, an**effective therapy for AD is perhaps the greatest unmet need facing modern medicine."**This project addresses the challenge of understanding neuron circuits in the brain involved in**memory, with the goal of improving the efficacy of neurostimulation therapies for AD and**dementia. Such treatments would stimulate specific brain circuits to promote memory**encoding and/or retrieval in patients with AD or dementia. The project will create a new type**of wireless, implantable deep brain probes for rodent experiments on memory loss rescue**that uses optical stimulation and electrical stimulation+recording of specific groups of**neurons. Importantly, these brain probes will be made using the same processes and**infrastructure as semiconductor microelectronics to ensure compatibility with volume**manufacturing and a viable technology translation path that will widely benefit neuroscientists**and clinical researchers.**This project brings together world-class expertise from around the globe in photonics,**electronics, neuroscience, and deep brain stimulation. In addition to the Canadian team**members, the project involves collaborators in France and United States who will provide**complementary expertise in the design, fabrication, and testing of the neural probes. The**results of this international project will benefit the health of Canadians and lead to high-value**neurotechnology products that are designed and integrated in Canada.

随着加拿大人口的平均年龄和发达国家的增长，**神经退行性状况将变得越来越普遍，并且对**医疗体系和经济的负担不断增长。主要神经退行性疾病是阿尔茨海默氏症**疾病（AD），这会导致记忆和认知丧失。 AD和痴呆症影响了大约1.1 **百万加拿大人，在加拿大每年的经济成本为10.4B美元。目前，**没有治愈或有效的治疗方法。柳叶刀神经病学委员会最近表示，对AD的有效疗法也许是面临现代药物的最大不需要的需求。痴呆症。该项目将创建一种新型的**，用于啮齿动物损失的啮齿动物实验**，使用光学刺激和电气刺激+记录特定组的**，以确保使用相同的工艺和**基础结构途径，这个项目广泛受益于神经科学家**和临床研究人员。除了加拿大团队**成员外，该项目还涉及法国和美国的合作者，他们将在神经探针的设计，制造和测试中提供**补充专业知识。这个国际项目的**结果将使加拿大人的健康受益，并导致在加拿大设计和集成的高价值**神经技术产品。