A novel bi-directional relationship between neuropathic pain and sleep.

神经性疼痛和睡眠之间的新型双向关系。

• 批准号: 424022-2013
• 负责人: Pang, Daniel
• 金额: $ 2.11万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=661465
• 关键词: novel; bi; directional; relationship; between; novel; bi; directional; relationship; between

Neuropathic pain results from damage to the nervous system. Common causes include diseases such as diabetes (painful diabetic neuropathy), and trauma such as spinal cord injury. This type of pain is poorly understood, difficult to manage and has widespread consequences for quality of life. One of the most common complications described by patients is sleep disruption, though it is presently unclear if it is a direct result of pain itself or as a side effect of pain medication, or both. Additionally, there is early evidence that sleep disruption itself can result in a worsening of neuropathic pain. In the presence of neuropathic pain it may be that management of sleep patterns is just as important as treating pain itself. My programme of research focuses on this inter-relationship between neuropathic pain and sleep. I use a robust animal model of neuropathic pain, spinal cord injury, to study neuropathic pain and its effects on sleep, and vice versa. In my lab, we have unique tools to enable us to record sleep in freely moving animals, enabling them to exhibit normal behaviour. Combining these tools with established skills in assessing pain, we will be able to discover if: 1. neuropathic pain results in sleep disruption and the form this disruption takes (e.g. difficulty falling asleep) and 2. how manipulation of sleep patterns affects neuropathic pain. The findings of this research have important implications for our understanding of how pain and sleep modulate each other, increasing our ability to study each situation more effectively and ultimately provide more effective management of patients with neuropathic pain. It is anticipated that what we learn from our model will apply to other causes of of neuropathic pain. This research programme will also provide valuable training and experience for trainees of all levels (undergraduate and graduate students, and technicians), preparing them for careers in academia, government and industry.****

神经性疼痛是由于对神经系统的损害而导致的。常见原因包括糖尿病（疼痛糖尿病神经病）和脊髓损伤等疾病。这种疼痛知之甚少，难以管理，并且对生活质量产生了广泛的后果。患者描述的最常见并发症之一是睡眠中断，尽管目前尚不清楚这是疼痛本身还是止痛药的副作用，还是两者兼而有之。此外，有早期的证据表明睡眠破坏本身可能导致神经性疼痛的恶化。在神经性疼痛的情况下，睡眠模式的管理可能与治疗疼痛本身一样重要。我的研究计划着重于神经性疼痛与睡眠之间的这种相互关系。我使用一种健壮的神经性疼痛，脊髓损伤的动物模型来研究神经性疼痛及其对睡眠的影响，反之亦然。在我的实验室中，我们有独特的工具，使我们能够在自由移动的动物中记录睡眠，从而表现出正常的行为。将这些工具与评估疼痛的既定技能相结合，我们将能够发现：1。神经性疼痛会导致睡眠中断和这种干扰所采取的形式（例如难以入睡）和2。睡眠模式的操纵如何影响神经性疼痛。这项研究的发现对我们对疼痛和睡眠如何相互调节的理解具有重要意义，增强了我们更有效地研究每种情况的能力，并最终提供了对神经性疼痛患者的更有效管理。可以预料，我们从模型中学到的知识将适用于神经性疼痛的其他原因。该研究计划还将为各级学员（本科生和研究生以及技术人员）提供宝贵的培训和经验，并为他们为学术界，政府和行业的职业做准备。****