Effect of essential oil compounds on aquaculture pathogens in combination with organic acids

精油化合物与有机酸组合对水产养殖病原体的影响

• 批准号: 522024-2018
• 负责人: Charette, Steve
• 金额: $ 0.91万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=647223
• 关键词: Effect; essential; oil; compounds; aquaculture

Aquaculture worldwide is one of the fastest growing animal production industries. However, rearing fish**populations in high density represent a high risk of invasion and transmission of pathogenic species, making**disease outbreaks really frequent. Consequently, productivity and profitability of aquaculture are often**compromised. Jefo Nutrition Inc. (Jefo) is very active in animal nutrition to address these issues providing**solutions with non-medicated feed additives. Despite research initiated on other related subjects (in poultry or**swine), Jefo is lacking data in order to be able to design new feed additives helping aquaculture production. A**better understanding of the effects of various purified compounds from essential oils on pathogens specific to**various commercially farmed aquaculture species in Canada and worldwide would help to expand the product**line of Jefo with the objective to provide more effective solutions to the issues related to common pathogenic**disease outbreaks. In a first project supported by an Engage grant, it was possible to make the following**advances regarding the effect of essential oils on selected fish pathogens: 1- identification of the most effective**essential oil compounds as well as their effective concentrations in various contexts and 2- first evidence of**synergetic effect with organic acids and 3- possible mechanisms of this effect through modification of the**surface of the bacteria. In the next step of this project, the effect of the combination of the various**concentrations of cinnamaldehyde and various concentrations of organic acids on pathogens will be addressed.**Other aspects of the effect of the treatment will also be explored including the effect on the morphology of the**bacteria, the loss of surface proteins as well as the effect on biofilm and virulence. This second step will be**decisive for the potential use of essential oils by Jefo in aquaculture-oriented products.

全球水产养殖是增长最快的动物生产行业之一。然而，高密度养殖鱼类**种群意味着病原物种入侵和传播的高风险，使得**疾病爆发非常频繁。因此，水产养殖的生产力和盈利能力往往**受到损害。 Jefo Nutrition Inc. (Jefo) 在动物营养领域非常活跃，致力于通过非药物饲料添加剂提供**解决方案来解决这些问题。尽管针对其他相关主题（家禽或**猪）开展了研究，但 Jefo 仍缺乏数据来设计有助于水产养殖生产的新饲料添加剂。 **更好地了解从精油中提取的各种纯化化合物对加拿大和世界范围内各种商业养殖水产养殖物种特有的病原体的影响，将有助于扩大 Jefo 的产品线**，目标是提供更有效的解决方案与常见致病**疾病爆发相关的问题。在由 Engage 赠款支持的第一个项目中，在精油对选定鱼类病原体的影响方面可以取得以下**进展： 1- 鉴定最有效的**精油化合物及其在水中的有效浓度各种背景和 2- 与有机酸的协同效应的第一个证据，以及 3- 通过改变细菌表面的这种效应的可能机制。在该项目的下一步中，将解决不同**浓度的肉桂醛和不同浓度的有机酸的组合对病原体的影响。**还将探讨治疗效果的其他方面，包括效果对**细菌的形态、表面蛋白的损失以及对生物膜和毒力的影响。第二步对于 Jefo 在水产养殖产品中潜在使用精油具有决定性作用。