Innovative approaches using biological systems and processes for mitigating the challenges in biotechnology and the environment

利用生物系统和工艺缓解生物技术和环境挑战的创新方法

基本信息

批准号：
170124-2011
负责人：
Bassi, Amarjeet
金额：
$ 2.91万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2017
资助国家：
加拿大
起止时间：
2017-01-01 至 2018-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=637943
关键词：
Innovative approaches using biological systems

项目摘要

New challenges have emerged for humanity in the 21st century which include "carbon capture", "nitrogen cycle and nutrient management", "clean and safe water" and "engineering better medicines and technology" as some of the significant issues of concern. In addition to the environmental and societal benefits, better and novel solutions to these specific challenges can lead to the generation of new industry, spin-offs, jobs and other activities over both the short and long term. In this proposed research program, which builds on existing research strengths, and the principles of biochemical and bio-environmental engineering, innovative approaches are proposed in the areas of health, nutrient management and clean water. Three specific projects are proposed. The first project utilizes a fluidized ion exchange technology as an alternative approach to overcome challenges related to the refolding of recombinant proteins. The second project focuses on removal of nutrients (ammonium, nitrates and phosphates) using a combination of ion exchange and halophilic microalgae. The third project addresses the important and difficult area of metal removal from saline waste waters and proposes to initiate a new direction of research at UWO with significant potential to address the issues of "clean and safe water". The proposed research will train 6 HQP (4 PhD and 2 MESc) over the duration of this study. The proposed research has potential to attract new funding and collaborations from Industry and other government agencies both nationally and Internationally.

21世纪的人类已经出现了新的挑战，其中包括“碳捕获”，“氮气周期和营养管理”，“清洁，安全的水”和“工程更好的药物和技术”，这是一些重要的问题。除了环境和社会利益外，针对这些特定挑战的更好和新颖的解决方案还可以导致短期和长期的新产业，衍生产品，工作和其他活动的产生。在这项拟议的研究计划中，基于现有的研究优势以及生物化学和生物环境工程的原则，在健康，营养管理和清洁水领域提出了创新方法。提出了三个特定的项目。第一个项目利用流化的离子交换技术作为克服与重组蛋白重新折叠有关的挑战的替代方法。第二个项目的重点是使用离子交换和卤素微藻的结合去除营养（铵，硝酸盐和磷酸盐）。第三个项目介绍了从盐水废水中去除金属的重要且困难的领域，并提议在UWO上启动新的研究方向，并具有很大潜力，以解决“清洁和安全水”的问题。拟议的研究将在本研究期间培训6 HQP（4 phD和2 MESC）。拟议的研究有可能吸引来自国内和国际政府机构的新资金和合作。