Investigation of GABAA-R PAM-stimulated beta-cell regeneration and its correction of hyperglycemia and glucose intolerance in prediabetes and type 2 diabetes

GABAA-R PAM 刺激的 β 细胞再生及其对糖尿病前期和 2 型糖尿病高血糖和葡萄糖耐受不良的校正的研究

• 批准号: 379175
• 负责人: Untereiner Ashley
• 金额: $ 4.92万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-11-01 至 2020-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=379175&lang=en
• 关键词: Beta-Cell Proliferation; Gaba; Pre-Diabetes; Regenerative Medicine; Type 2 Diabetes; Beta-Cell Proliferation; Gaba; Pre-Diabetes; Regenerative Medicine; Type 2 Diabetes

The development of medications to safely promote ß-cell replication would be ground-breaking for the treatment of all forms of diabetes. GABA, a neurotransmitter, was shown to facilitate ß-cell regeneration in mice. However, GABA exerts unspecific effects

用于安全促进β细胞复制的药物的开发将是为了治疗所有形式的糖尿病。 GABA是一种神经递质，显示可促进小鼠的ß细胞再生。但是，GABA发挥了不明确的效果