Development of one-pot sequential cyclizations and applications towards the synthesis of complex alkaloids / Développement de cyclisations séquentielles monotopes et applications à la synthèse d’alcaloïdes complexes

一锅顺序环化的开发及其在复杂生物碱合成中的应用/Développement de cycloplications séquentielles monotopes et applications à la Synèse dâalcaloïdes Complexes

• 批准号: RGPIN-2017-05400
• 负责人: Bélanger, Guillaume
• 金额: $ 1.6万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632793
• 关键词: Development; pot; sequential; cyclizations; applications

This research program is aimed at developing original strategies to efficiently synthesize complex natural products through new cascades of reactions. In this vein, the research proposed is divided into three orientations (see below). This proposed research program will have a significant impact in the community of organic chemists since it will provide innovative and efficient ways to access complex alkaloids and motifs that are hard to obtain using the currently available methods. Such a program is perfectly suited for the formation of highly qualified personnel destined to pharmaceutical industry and academia.

该研究计划旨在开发原创策略，通过新的级联反应有效合成复杂的天然产物。在这方面，所提出的研究分为三个方向（见下文）。这项拟议的研究计划将对有机化学家界产生重大影响，因为它将提供创新且有效的方法来获取使用当前可用方法难以获得的复杂生物碱和基序。这样的项目非常适合培养面向制药行业和学术界的高素质人才。