Lung micromechanical modelling using in vivo regional pulmonary functional magnetic resonance imaging

使用体内局部肺功能磁共振成像进行肺微机械建模

• 批准号: 402091-2011
• 负责人: Parraga, Grace
• 金额: $ 4.15万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573154
• 关键词: Lung; micromechanical; modelling; using; vivo

Recent advances in imaging methods dedicated to the lung include methods that involve inhaled gases that provide a unique magnetic resonance imaging (MRI) signal or contrast. These novel MRI methods as based on the magnetization (or hyperpolarization) of noble gases such as 3He and 129Xe and have been pioneered at a handful of imaging research centres (including ours) for measurements of lung function that until now have never been possible. The traditional view of lung function and mechanics has been derived from simple 2 compartment models and measurements developed using pressure and flow measurements at the mouth or tubes fixed to the end of the trachea of excised lungs. Despite the importance of these traditional approaches, it has unfortunately, not yet been possible to incorporate regional lung information to better develop lung models of function and mechanics. To directly address this decades-old problem, we propose to incorporate lung imaging measurements of airway and airspace structure and function into existing models of lung micromechanics and to develop new models and test these using regional functional imaging information. Therefore the overarching objective of our proposed research program is to develop new ways to use lung tissue and airway functional and structural quantitative measurements derived from 3He and 129Xe MR images in obstructive lung disease like asthma and COPD as well as healthy volunteers to generate and develop robust mathematical models of the biomechanics in healthy and diseased lung. This approach provides a way to incorporate, test and validate regional in vivo imaging measurements to generate novel micromechanical models of the lung.

肺部成像方法的最新进展包括涉及吸入气体的方法，这些方法可提供独特的磁共振成像 (MRI) 信号或对比度。 这些新颖的 MRI 方法基于 3He 和 129Xe 等稀有气体的磁化（或超极化），并已在少数成像研究中心（包括我们的中心）率先用于测量肺功能，而迄今为止这是不可能的。 肺功能和力学的传统观点源自简单的 2 室模型和测量，这些模型和测量是使用固定在切除肺气管末端的口腔或管子上的压力和流量测量来开发的。 尽管这些传统方法很重要，但不幸的是，尚不可能整合局部肺部信息来更好地开发肺部功能和力学模型。 为了直接解决这个已有数十年历史的问题，我们建议将气道和空域结构和功能的肺部成像测量纳入现有的肺部微力学模型中，并开发新模型并使用区域功能成像信息进行测试。 因此，我们提出的研究计划的总体目标是开发新方法，利用从 3He 和 129Xe MR 图像得出的肺组织和气道功能和结构定量测量结果来治疗哮喘和 COPD 等阻塞性肺病以及健康志愿者，以生成和开发稳健的肺组织和气道功能和结构定量测量结果。健康和患病肺部生物力学的数学模型。这种方法提供了一种整合、测试和验证局部体内成像测量的方法，以生成新颖的肺部微机械模型。