Lung micromechanical modelling using in vivo regional pulmonary functional magnetic resonance imaging

使用体内局部肺功能磁共振成像进行肺微机械建模

• 批准号: 402091-2011
• 负责人: Parraga, Grace
• 金额: $ 4.15万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573154
• 关键词: Lung; micromechanical; modelling; using; vivo

Recent advances in imaging methods dedicated to the lung include methods that involve inhaled gases that provide a unique magnetic resonance imaging (MRI) signal or contrast. These novel MRI methods as based on the magnetization (or hyperpolarization) of noble gases such as 3He and 129Xe and have been pioneered at a handful of imaging research centres (including ours) for measurements of lung function that until now have never been possible. The traditional view of lung function and mechanics has been derived from simple 2 compartment models and measurements developed using pressure and flow measurements at the mouth or tubes fixed to the end of the trachea of excised lungs. Despite the importance of these traditional approaches, it has unfortunately, not yet been possible to incorporate regional lung information to better develop lung models of function and mechanics. To directly address this decades-old problem, we propose to incorporate lung imaging measurements of airway and airspace structure and function into existing models of lung micromechanics and to develop new models and test these using regional functional imaging information. Therefore the overarching objective of our proposed research program is to develop new ways to use lung tissue and airway functional and structural quantitative measurements derived from 3He and 129Xe MR images in obstructive lung disease like asthma and COPD as well as healthy volunteers to generate and develop robust mathematical models of the biomechanics in healthy and diseased lung. This approach provides a way to incorporate, test and validate regional in vivo imaging measurements to generate novel micromechanical models of the lung.

用于肺部的成像方法的最新进展包括涉及提供独特磁共振成像（MRI）信号或对比度的吸入气体的方法。 这些新型的MRI方法基于诸如3HE和129XE等贵重气体的磁化（或超极化），并在少数成像研究中心（包括我们的）进行了开创性的肺部功能测量，直到现在到目前为止一直无法进行肺功能。 肺功能和力学的传统视图是从简单的2个隔室模型中得出的，并使用固定在切除肺部气管末端的口或管子的压力和流量测量中开发了测量。 尽管这些传统方法很重要，但不幸的是，尚不可能纳入区域肺部信息以更好地发展功能和力学的肺模型。 为了直接解决这个数十年历史的问题，我们建议将气道和空域结构和功能的肺成像测量结合到现有的肺微力学模型中，并开发新模型并使用区域功能成像信息进行测试。 因此，我们提出的研究计划的总体目标是开发新的方法来使用肺组织和气道功能和结构定量测量，这些定量测量源自阻塞性肺部疾病中的3HE和129XE MR图像，例如哮喘和COPD，以及健康的志愿者，以及健康的志愿者，以生成和发展健康和不良的lunk生物力学模型的可靠数学模型。这种方法提供了一种合并，测试和验证体内成像测量区域的方法，以生成肺的新型微机械模型。